Structure of PDB 8v6n Chain A Binding Site BS03

Receptor Information
>8v6n Chain A (length=636) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVFSKPMDSNIRQCRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDED
VPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRF
INAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPK
YQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHAL
VTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGK
AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSV
LEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNI
TLTLVSYYRPREEEGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQS
ILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY
TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKD
NKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILT
FVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRF
RMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNE
Ligand information
Ligand IDFZ4
InChIInChI=1S/C14H16BNO/c16-11-12-17-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10H,11-12,16H2
InChIKeyBLZVCIGGICSWIG-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01
OpenEye OEToolkits 2.0.6		B(c1ccccc1)(c2ccccc2)OCCN
CACTVS 3.385NCCOB(c1ccccc1)c2ccccc2
FormulaC14 H16 B N O
Name2-aminoethyl diphenylborinate
ChEMBLCHEMBL169233
DrugBank
ZINCZINC000169743034
PDB chain8v6n Chain A Residue 906 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8v6n TRPV3 activation by different agonists accompanied by lipid dissociation from the vanilloid site
Resolution2.59 Å
Binding residue
(original residue number in PDB)		S444 W493 C496 K500 Y564
Binding residue
(residue number reindexed from 1)		S341 W378 C381 K385 Y449
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8v6n, PDBe:8v6n, PDBj:8v6n
PDBsum8v6n
PubMed38691614
UniProtQ8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (Gene Name=TRPV3)

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