Structure of PDB 8v3q Chain A Binding Site BS03

Receptor Information

>8v3q Chain A (length=501) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NELRCGGLLFSSRFDSGNLAHVEKVESPDYEFNVWTRPDCAETEFENGNR
SWFYFSVRGGMPGKLIKINIMNMNKQSKLYSQGMAPFVRTLPTRPRWERI
RDRPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFSYSDCQELLNQLD
QRFPENHPTHSSPLDTIYYHRELLCYSLDGLRVDLLTITSCHGLREDREP
RLEQLFPDTSTPRPFRFAGKRIFFLSSRVHPGETPSSFVFNGFLDFILRP
DDPRAQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVL
HPAIYGAKAVLLYHHVHSRLTIPPKESGVAYYVDLHGHASKRGCFMYGNS
FSDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRQSKEGSGRV
AIYKASGIIHSYTLACNYNTGRSVNSIPAACHDNGRASPPPPPAFPSRYT
VELFEQVGRAMAIAALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRNSR
G

Ligand information

Ligand ID

GLU

InChI

InChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1

InChIKey

WHUUTDBJXJRKMK-VKHMYHEASA-N

SMILES

Software	SMILES
ACDLabs 12.01	O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0	C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0	C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370	N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370	N[CH](CCC(O)=O)C(O)=O

Formula

C5 H9 N O4

Name

GLUTAMIC ACID

PDB chain

8v3q Chain M Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8v3q Tubulin code eraser CCP5 binds branch glutamates by substrate deformation.
Resolution	3.1 Å
Binding residue (original residue number in PDB)	N312 R313 Y445 K495 S498 R500 T514
Binding residue (residue number reindexed from 1)	N290 R291 Y347 K394 S397 R399 T413
Annotation score	5

External links

PDB	RCSB:8v3q, PDBe:8v3q, PDBj:8v3q
PDBsum	8v3q
PubMed	39020174
UniProt	Q8NDL9\|CBPC5_HUMAN Cytosolic carboxypeptidase-like protein 5 (Gene Name=AGBL5)

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