BioLiP

>8uxi Chain A (length=4004) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLESTSNSKNVP
PDLSICTFVLEQSLSVRALQEMLANHRTLLYGHAILLRHSYSGMYLCCLS
TSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILV
SVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPISSGSEAAQGYLIGGDVL
RLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSVHARSLWRLETLRVAW
SGSHIRWGQPFRLRHVTTGKYLSLMEDKNLLLMDKEKADVKSTAFTFRSS
KEKLDVGVRKEVDGMGTSEIKYGDSVCYIQHVDTGLWLTYQSVDSIQRKA
IMHHEGHMDDGISLSRSQHEESRTARVIWSTVFLFNRFIRGLDALSKKAK
ASTVDLPIESVSLSLQDLIGYFHPPDEHLEHEDKQNRLRALKNRQNLFQE
EGMINLVLECIDRLHVYSSAAHFADVAGREAGESWKSILNSLYELLAALI
RGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKE
GHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRD
LLLQTRLVNHVSSMRPNIFLGVSEGSAQYKKWYYELMVDHTEPFVTAEAT
HLRVGWASTEGYSPYPGGGEEWGGNGVGDDLFSYGFDGLHLWSGCIARTV
SSPNQHLLRTDDVISCCLDLSAPSISFRINGQPVQGMFENFNIDGLFFPV
VSFSAGIKVRFLLGGRHGEFKFLPPPGYAPCYEAVLPKEKLKVEHSREYK
QERTYTRDLLGPTVSLTQAAFTPIPVDTSQIVLPPHLERIREKLAENIHE
LWVMNKIELGWQYGPVRDDNKRQHPCLVEFSKLPEQERNYNLQMSLETLK
TLLALGCHVGISDEHAEDKVKKMKLPKNYQLTSGYKPAPMDLSFIKLTPS
QEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNRRNPRLVPYTLLDDR
TKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARAEVCSGTGERFRIFRAE
KTYAVKAGRWYFEFETVTAGDMRVGWSRPGCQPDQELGSDERAFAFDGFK
AQRWHQGNEHYGRSWQAGDVVGCMVDMNEHTMMFTLNGEILLDDSGSELA
FKDFDVGDGFIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAV
NTNRDITMWLSKRLPQFLQVPSNHEHIEVTRIDGTIDSSPCLKVTQKSFG
SQNSNTDIMFYRLSMPIECAEVFSKRDDYDFLMQTSTYYYSVRIFPGQEP
ANVWVGWITSDFHQYDTGFDLDRVRTVTVTLGDEKGKVHESIKRSNCYMV
CAGESMSPGQGRNNNGLEIGCVVDAASGLLTFIANGKELSTYYQVEPSTK
LFPAVFAQATSPNVFQFELGRIKNVMPLSAGLFKSEHKNPVPQCPPRLHV
QFLSHVLWSRMPNQFLKVDVSRISERQGWLVQCLDPLQFMSLHIPEENRS
VDILELTEQEELLKFHYHTLRLYSAVCALGNHRVAHALCSHVDEPQLLYA
IENKYMPGLLRAGYYDLLIDIHLSSYATARLMMNNEYIVPMTEETKSITL
FPDENKKHGLPGIGLSTSLRPRMQFSSPSFVSISNECYQYSPEFPLDILK
SKTIQMLTEAVKEGSLHARDPVGGTTEFLFVPLIKLFYTLLIMGIFHNED
LKHILQLIEPSVFKEAPKEGLLQMKLPEPVKLQMCLLLQYLCDCQVRHRI
EAIVAFSDDFVAKLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQ
INMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIEKKSSTLQQLISE
TMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVE
DTINLLASLGQIRSLLSVRMGKEEEKLMIRGLGDIMNNKVFYQHPNLMRA
LGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAM
FDHLSYLLENSSVGLASPAMRGSTPLDVAAASVMDNNELALALREPDLEK
VVRYLAGCGLQSCQMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVE
ENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKIAEDPSRDGPSP
EEDDTIHMGNAIMTFYSALIDLLGRCAPEMHLIHAGKGEAIRIRSILRSL
IPLGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVY
GIEVQDFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLP
LLTRCAPLFAGTEHHASLIDSLLHTVYRLSKGCSLTKAQRDSIEVCLLSI
CGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLKLLTNHYERCWKYYCLPGG
WGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPCLSAVAGAL
PPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAE
HSHDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIK
ESLKTMLAWGWRIERTREGDSMALYNGYSPRAIDMSNVTLSRDLHAMAEM
MAENYHNIWAKKKKMELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDIL
KFLQINGYAVSRGFKDLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEF
DGGSRGKGEHFPYEQEIKFFAKVVLPLIDQYFKNHRLYFLSAASRPLCSG
GHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDAR
TVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTKGVTQIINYTTV
ALLPMLSSLFEHIGQHQFVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIE
TEEHYFEDKLIEDLAKPGAEPPEEDEGTKRVDPLHQLILLFSRTALTEKC
KLEEDFLYMAYADIMAKSCHDEEVKSFEEKEMEKQKLLYQQARLHDRGAA
EMVLQTISASKGETGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDV
GFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVLQDDEFTC
DLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISD
FYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPCTGNQQSLAH
SRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLE
GNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDP
DGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRF
HEPAKDIGFNVAVLLTNLSEHMPNDTRLQTFLELAESVLNYFQPFLGRIE
IMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKME
LFVNFCEDTIFEMQLAAQISESSILTVRSALFALRYNILTLMRMLSLKSL
KKQMKKVKKMTVKDMVTAFFSSYWSIFMTLLHFVASVFRGFFRIICFWKK
IIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTIAVHYVLEE
SSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFD
GLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGR
DRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMWKLGVV
FTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHN
GKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCY
MFHMYVGVRAGGGIGDEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQ
GLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEH
NLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYE
DQLN

Software

SMILES

CACTVS 3.341

[Ca++]

ACDLabs 10.04
OpenEye OEToolkits 1.5.0

[Ca+2]

Molecular Function

GO:0005216

monoatomic ion channel activity

GO:0005219

ryanodine-sensitive calcium-release channel activity

GO:0005262

calcium channel activity

calcium ion binding

protein binding

calmodulin binding

intracellularly gated calcium channel activity

GO:0019899

enzyme binding

GO:0019901

protein kinase binding

GO:0034236

protein kinase A catalytic subunit binding

GO:0034237

protein kinase A regulatory subunit binding

GO:0042802

identical protein binding

GO:0043924

suramin binding

GO:0044325

transmembrane transporter binding

GO:0048763

calcium-induced calcium release activity

GO:0097159

organic cyclic compound binding

	Biological Process
GO:0001666	response to hypoxia
GO:0002027	regulation of heart rate
GO:0003143	embryonic heart tube morphogenesis
GO:0003220	left ventricular cardiac muscle tissue morphogenesis
GO:0003300	cardiac muscle hypertrophy
GO:0005513	detection of calcium ion
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0006874	intracellular calcium ion homeostasis
GO:0006941	striated muscle contraction
GO:0010460	positive regulation of heart rate
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0010882	regulation of cardiac muscle contraction by calcium ion signaling
GO:0014808	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014850	response to muscle activity
GO:0019722	calcium-mediated signaling
GO:0031000	response to caffeine
GO:0035994	response to muscle stretch
GO:0051209	release of sequestered calcium ion into cytosol
GO:0051284	positive regulation of sequestering of calcium ion
GO:0051480	regulation of cytosolic calcium ion concentration
GO:0051649	establishment of localization in cell
GO:0051775	response to redox state
GO:0055085	transmembrane transport
GO:0055117	regulation of cardiac muscle contraction
GO:0060048	cardiac muscle contraction
GO:0060402	calcium ion transport into cytosol
GO:0070296	sarcoplasmic reticulum calcium ion transport
GO:0070588	calcium ion transmembrane transport
GO:0071313	cellular response to caffeine
GO:0071872	cellular response to epinephrine stimulus
GO:0072599	establishment of protein localization to endoplasmic reticulum
GO:0086005	ventricular cardiac muscle cell action potential
GO:0086029	Purkinje myocyte to ventricular cardiac muscle cell signaling
GO:0086064	cell communication by electrical coupling involved in cardiac conduction
GO:0097050	type B pancreatic cell apoptotic process
GO:0097553	calcium ion transmembrane import into cytosol
GO:0098735	positive regulation of the force of heart contraction
GO:0098904	regulation of AV node cell action potential
GO:0098907	regulation of SA node cell action potential
GO:0098910	regulation of atrial cardiac muscle cell action potential
GO:0098911	regulation of ventricular cardiac muscle cell action potential

Biological Process

GO:0001666

response to hypoxia

GO:0002027

regulation of heart rate

GO:0003143

embryonic heart tube morphogenesis

GO:0003220

left ventricular cardiac muscle tissue morphogenesis

GO:0003300

cardiac muscle hypertrophy

GO:0005513

detection of calcium ion

GO:0006811

monoatomic ion transport

GO:0006816

calcium ion transport

GO:0006874

intracellular calcium ion homeostasis

GO:0006941

striated muscle contraction

GO:0010460

positive regulation of heart rate

GO:0010881

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

GO:0010882

regulation of cardiac muscle contraction by calcium ion signaling

GO:0014808

release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

GO:0014850

response to muscle activity

GO:0019722

calcium-mediated signaling

GO:0031000

response to caffeine

GO:0035994

response to muscle stretch

GO:0051209

release of sequestered calcium ion into cytosol

GO:0051284

positive regulation of sequestering of calcium ion

GO:0051480

regulation of cytosolic calcium ion concentration

GO:0051649

establishment of localization in cell

GO:0051775

response to redox state

GO:0055085

transmembrane transport

GO:0055117

regulation of cardiac muscle contraction

GO:0060048

cardiac muscle contraction

GO:0060402

calcium ion transport into cytosol

GO:0070296

sarcoplasmic reticulum calcium ion transport

GO:0070588

calcium ion transmembrane transport

GO:0071313

cellular response to caffeine

GO:0071872

cellular response to epinephrine stimulus

GO:0072599

establishment of protein localization to endoplasmic reticulum

GO:0086005

ventricular cardiac muscle cell action potential

GO:0086029

Purkinje myocyte to ventricular cardiac muscle cell signaling

GO:0086064

cell communication by electrical coupling involved in cardiac conduction

GO:0097050

type B pancreatic cell apoptotic process

GO:0097553

calcium ion transmembrane import into cytosol

GO:0098735

positive regulation of the force of heart contraction

GO:0098904

regulation of AV node cell action potential

GO:0098907

regulation of SA node cell action potential

GO:0098910

regulation of atrial cardiac muscle cell action potential

GO:0098911

regulation of ventricular cardiac muscle cell action potential

	Cellular Component
GO:0005790	smooth endoplasmic reticulum
GO:0005886	plasma membrane
GO:0014701	junctional sarcoplasmic reticulum membrane
GO:0016020	membrane
GO:0016529	sarcoplasmic reticulum
GO:0030017	sarcomere
GO:0030018	Z disc
GO:0032991	protein-containing complex
GO:0033017	sarcoplasmic reticulum membrane
GO:0034704	calcium channel complex
GO:0042383	sarcolemma

Cellular Component

GO:0005790

smooth endoplasmic reticulum

GO:0005886

plasma membrane

GO:0014701

junctional sarcoplasmic reticulum membrane

GO:0016020

membrane

GO:0016529

sarcoplasmic reticulum

GO:0030017