Structure of PDB 8uis Chain A Binding Site BS03

Receptor Information
>8uis Chain A (length=1415) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPR
QGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVC
FFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGCGRY
QPRIRRSGLELYAEWKILLSPERVHEIFKRISDEECFVLGMEPRYARPEW
MIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNG
AAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKE
GRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPF
NIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVE
RHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFD
GDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRK
FTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIP
GHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGT
SAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSK
TYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILND
ARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKR
IPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGL
IDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLA
GESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAH
IQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHIN
PRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRS
TLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGE
PATQMTLNKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKD
ILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVAR
ISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLV
LRIRIMNSDDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLG
IEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVN
RQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGC
FDLLLDAEKCKYGME
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8uis Distinct negative elongation factor conformations regulate RNA polymerase II promoter-proximal pausing.
Resolution3.23 Å
Binding residue
(original residue number in PDB)		K331 S332 R334 K346 R364 Q461 T854 Y859 R862 E1433 E1434
Binding residue
(residue number reindexed from 1)		K284 S285 R287 K299 R317 Q414 T807 Y812 R815 E1363 E1364
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8uis, PDBe:8uis, PDBj:8uis
PDBsum8uis
PubMed38401543
UniProtA0A8D1DPV6

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