Structure of PDB 8u0p Chain A Binding Site BS03

Receptor Information
>8u0p Chain A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINAL
KSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLE
LFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLER
MPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPD
GRSHRGIFSRLLDSLRQEGFLTDDLVSQGKYLGVCRLPGPGRRHRRLDII
VVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVGRVLPT
PTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8u0p DNA polymerase lambda Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Y267 W274 R275 Y279 P303 G304 G306 M309 K312
Binding residue
(residue number reindexed from 1)		Y31 W38 R39 Y43 P67 G68 G70 M73 K76
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8u0p, PDBe:8u0p, PDBj:8u0p
PDBsum8u0p
PubMed38428373
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

[Back to BioLiP]