Structure of PDB 8tzg Chain A Binding Site BS03

Receptor Information
>8tzg Chain A (length=906) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NRMKLMIVGNTGSGKTTLLQQTVGIDVKDWPLVLNVWDFAREEFYSTHPH
FMTQRALYLAVAMKPWLFNIKARASSSPVILVGTAIRDYHFVLAKLRKTI
INESLNFKIRDVELEKIILSERKNVPIEFPVIDRKRLLQLVRNELPHAVH
FLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILKGIISRRDVEKFM
SQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYE
MPYFPMGFWSRLINRLLEISPYMLSGALRPNRMYWRQGIYLNWSPEAYCL
VGSEVESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLTLLKKWAL
YSFNDGEEHQKILLDDLMKKAEEGDLLVNIPISQIAPDLILADLPRNIML
NNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTL
QHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGT
AQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTG
GRIVEGLKFPNEFDELEGKLPDPVKEYGCAPWPMVEKLIKQCLKENPQER
PTSAQVFDILNSAELVCLTRILLPKNVIVECMVASIWLGCQLSFLILCLA
LVHIVSGTCLYCLLVGTGKLAIPLMCLSESVMWGGCGTKIFSFSIQKLIE
TRTSQLFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLI
DCVHFLREVYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYN
FCNSVRVMMTAQNVMLVLGYNRIQSCLTVWDINLPHEVQNLEKHIEVRKE
LAEKMR
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8tzg Chain A Residue 2603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tzg Inhibition of Parkinson Disease-related LRRK2 by Type I and Type II kinase inhibitors:activity and structures
Resolution2.7 Å
Binding residue
(original residue number in PDB)		T1348 T1368
Binding residue
(residue number reindexed from 1)		T16 T22
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
3.6.5.-
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0005525 GTP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8tzg, PDBe:8tzg, PDBj:8tzg
PDBsum8tzg
PubMed38039358
UniProtQ5S007|LRRK2_HUMAN Leucine-rich repeat serine/threonine-protein kinase 2 (Gene Name=LRRK2)

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