Structure of PDB 8th9 Chain A Binding Site BS03

Receptor Information

>8th9 Chain A (length=253) Species: 13616 (Monodelphis domestica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PEGPSLRKFHQLVAPFVGQLVVTVGGNSKKINPNMLEMLRLQDSQVHGKN
LYLNFGLTSGLWLCFHFGLFGSVRASELSRATKANKRWKDPIPRLVLHFA
KGFLAFYNCRIYWCLGPTVKPTSDILSEEFDRRQALEALKQASPVSYTLL
DQRYFAGLGNIIKNEVLYLARIHPLSLGSCLTPLNLESLLDHVVSFSVGW
LQKKLEGKPLHHLIYQKEQCPAGHQVMKDSFGPPGSFQRLTWWCPHCQPK
AEE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8th9 Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8th9 Structural and biochemical insights into NEIL2's preference for abasic sites
Resolution	2.08 Å
Binding residue (original residue number in PDB)	C294 H298 C318 C321
Binding residue (residue number reindexed from 1)	C220 H224 C244 C247
Annotation score	1

Enzymatic activity

Enzyme Commision number

4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003684	damaged DNA binding
GO:0003906	DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270	zinc ion binding
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104	DNA N-glycosylase activity

	Biological Process
GO:0006284	base-excision repair

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Molecular Function

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Biological Process

External links

PDB	RCSB:8th9, PDBe:8th9, PDBj:8th9
PDBsum	8th9
PubMed	37971311
UniProt	F7AMK3

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