Structure of PDB 8t5s Chain A Binding Site BS03

Receptor Information
>8t5s Chain A (length=693) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLCLRNYQEELCQVALQGKNTIVTAPTGSGKTVIAANIIKEHFESRSSEG
KRFKALFMTPNSMILNQQAASISSYLDHVYHTQIIQGSDNVPTRNVIQSK
DLIVATPQMIVNLCNEHRNSLDSRLDQFFLSTFTIIFFDECHNTVKNSPY
SNIMREYHYLKNMGNMPEGHSLPQIIGLTASLGTGDKNDCLQVRNYIAGL
CASMDVKDLSIVKDNLEELRGYSPIVPDKVLLCERSTDGPIGMFTNRLTL
MMQEVEGLIRTALRNEHIGSFLDPPADKEHAGYQNWVCNQMNLVSGTSFR
ETGTRTIINEALDVLKECFCTLSYNINFHPEVALNYLKDEMEYRTPNFTV
NMIRIWERYHNQLVGTGSAENPMISKTVQYIVEQNLQRADSRTIIFVRTR
YEATILNKVLNSNEELLMLGIKSEWMSGLNKSTASSADISASKQKQMEKL
KMFADGEIRILVSTSVAEEGLDVPECSLVIKYNYATNEIAHVQRRGRGRA
LNSECVLITNSIALRDQESNNRDKESLMSETISLIQNSPAEFRKCVDEES
NKIWPRILREDTDKAQKIEEQINRNIVYKIICKKCEAILCTSKDIRSRNT
QYLVCDPGFWSLVRKTRTGSINCRRENCGLKLGQLIEVNTVDLPCLSALS
IVLLVEGTDKRIIVKKWKNILDKYFTPTEIRQLDVQTMRDADQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8t5s Chain A Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8t5s C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA
Resolution2.9 Å
Binding residue
(original residue number in PDB)		C891 C945
Binding residue
(residue number reindexed from 1)		C582 C623
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t5s, PDBe:8t5s, PDBj:8t5s
PDBsum8t5s
PubMed38747717
UniProtG5EDI8

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