Structure of PDB 8sl1 Chain A Binding Site BS03

Receptor Information
>8sl1 Chain A (length=843) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GLPILYFSGRRERLLLRPEVLAEIPREAFTVEAWVKPEGGQNNPAIIAGV
FDNCSHTVSDKGWALGIRSGKDKGKRDARFFFSLCTDRVKKATILISHSR
YQPGTWTHVAATYDGRHMALYVDGTQVASSLDQSGPLNSPFMASCRSLLL
GGDSSEDGHYFRGHLGTLVFWSTALPQSHFQHSSQHSSGEEEATDLVLTA
SFEPVNTEWVPFRDEKYPRLEVLQGFEPEPEILSPLQPPLCGQTVCDNVE
LISQYNGYWPLRGEKVIRYQVVNICDDIVSEEQIRLQHEALNEAFSRYNI
SWQLSVHQVHNSTLRHRVVLVNCEPSKIGNDHCDPECEHPLTGTCFDPDS
PKRAYMSVKELKEALQLNSTHFLNIYFASSVREDLAGAATWPWDKDAVTH
LGGIVLSPAYYGMPGHTDTMIHQVGHVLGLYHVFKGVSERESCNDPCKET
VPSMETGDLCADTAPTPKSELCREPEPTTRFPGAPFTNYMSYTDDNCTDN
FTPNQVARMHCYLDLVYQQWTESRKPTPIPIPPMVIGQTNKSLTIHWLPP
ISGVVYDRASGSLCGACTEDGTFRQYVHTASSRRVCDSSGYWTPEEAVGP
PDVDQPCEPSLQAWSPEVHLYHMNMTVPCPTEGCSLELLFQHPVQADTLT
LWVTSFFMESSQVLFDTEILLENKESVHLGPLDTFCDIPLTIKLHVDGKV
SGVKVYTFDERIEIDAALLTSQPHSPLCSGCRPVRYQVLRDPPFASGLPV
VVTHSHRKFTDVEVTPGQMYQYQVLAEAGGELGEASPPLNHIHGAPYCGD
GKVSERLGEECDDGDLVSGDGCSKVCELEEGFNCVGEPSLCYM
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8sl1 Chain A Residue 1804 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sl1 Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition
Resolution3.13 Å
Binding residue
(original residue number in PDB)		Y880 C881 D883 K885 E892 D895
Binding residue
(residue number reindexed from 1)		Y797 C798 D800 K802 E809 D812
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.-
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:8sl1, PDBe:8sl1, PDBj:8sl1
PDBsum8sl1
PubMed37898658
UniProtQ9BXP8|PAPP2_HUMAN Pappalysin-2 (Gene Name=PAPPA2)

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