Structure of PDB 8sj2 Chain A Binding Site BS03
Receptor Information
>8sj2 Chain A (length=355) Species:
10090
(Mus musculus) [
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GPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQL
NTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFNPLSHF
LEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNP
EEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKN
AKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLM
KYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDK
LLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGF
PIFDK
Ligand information
>8sj2 Chain I (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8sj2
Structure of ternary complex of cGAS with dsDNA and bound ATP and 2'-dGTP
Resolution
2.23 Å
Binding residue
(original residue number in PDB)
K335 T338
Binding residue
(residue number reindexed from 1)
K184 T187
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8sj2
,
PDBe:8sj2
,
PDBj:8sj2
PDBsum
8sj2
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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