Structure of PDB 8sfn Chain A Binding Site BS03 |
| >8sfn Chain A (length=1302) Species: 1111120 (Acidaminococcus sp. BV3L6)
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MTQFEGFTNLYQVSKTLRFELIPQGKTLKHIQEQGFIEEDKARNDHYKEL
KPIIDRIYKTYADQCLQLVQLDWENLSAAIDSYRKEKTEETRNALIEEQA
TYRNAIHDYFIGRTDNLTDAINKRHAEIYKGLFKAELFNGKVLKQLGTVT
TTEHENALLRSFDKFTTYFSGFYENRKNVFSAEDISTAIPHRIVQDNFPK
FKENCHIFTRLITAVPSLREHFENVKKAIGIFVSTSIEEVFSFPFYNQLL
TQTQIDLYNQLLGGISREAGTEKIKGLNEVLNLAIQKNDETAHIIASLPH
RFIPLFKQILSDRNTLSFILEEFKSDEEVIQSFCKYKTLLRNENVLETAE
ALFNELNSIDLTHIFISHKKLETISSALCDHWDTLRNALYERRISELKSA
KEKVQRSLKHEDINLQEIISAAGKELSEAFKQKTSEILSHAHAALDQPLP
TTLKKQEEKEILKSQLDSLLGLYHLLDWFAVDESNEVDPEFSARLTGIKL
EMEPSLSFYNKARNYATKKPYSVEKFKLNFQMPTLASGWDVNKEKNNGAI
LFVKNGLYYLGIMPKQKGRYKALSFEPTEKTSEGFDKMYYDYFPDAAKMI
PKCSTQLKAVTAHFQTHTTPILLSNNFIEPLEITKEIYDLNNPEKEPKKF
QTAYAKKTGDQKGYREALCKWIDFTRDFLSKYTKTTSIDLSSLRPSSQYK
DLGEYYAELNPLLYHISFQRIAEKEIMDAVETGKLYLFQIYNKDFAKGHH
GKPNLHTLYWTGLFSPENLAKTSIKLNGQAELFYRPKSRMKRMAHRLGEK
MLNKKLKDQKTPIPDTLYQELYDYVNHRLSHDLSDEARALLPNVITKEVS
HEIIKDRRFTSDKFFFHVPITLNYQAANSPSKFNQRVNAYLKEHPETPII
GIDRGERNLIYITVIDSTGKILEQRSLNTIQQFDYQKKLDNREKERVAAR
QAWSVVGTIKDLKQGYLSQVIHEIVDLMIHYQAVVVLENLNFGFKSKRTG
IAEKAVYQQFEKMLIDKLNCLVLKDYPAEKVGGVLNPYQLTDQFTSFAKM
GTQSGFLFYVPAPYTSKIDPLTGFVDPFVWKTIKNHESRKHFLEGFDFLH
YDVKTGDFILHFKMNRNLSFQRGLPGFMPAWDIVFEKNETQFDAKGTPFI
AGKRIVPVIENHRFTGRYRDLYPANELIALLEEKGIVFRDGSNILPKLLE
NDDSHAIDTMVALIRSVLQMRNSNAATGEDYINSPVRDLNGVCFDSRFQN
PEWPMDADANGAYHIALKGQLLLNHLKESKDLKLQNGISNQDWLAYIQEL
RN |
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| PDB | 8sfn WT CRISPR-Cas12a with a 16bp R-loop and nontarget strand in the RuvC active site. |
| Resolution | 3.3 Å |
Binding residue
(original residue number in PDB) | K87 E89 R92 K134 A135 K164 F165 T166 T167 Q286 N288 E372 W382 P538 K570 R574 Y575 A602 K603 K607 Q611 K653 Q656 T657 D706 E911 F999 R1003 A1053 K1054 A1067 P1068 T1070 S1071 K1072 R1127 R1168 F1169 N1291 |
Binding residue
(residue number reindexed from 1) | K87 E89 R92 K134 A135 K164 F165 T166 T167 Q286 N288 E372 W382 P533 K565 R569 Y570 A597 K598 K602 Q606 K648 Q651 T652 D701 E906 F994 R998 A1048 K1049 A1062 P1063 T1065 S1066 K1067 R1122 R1163 F1164 N1286 |
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