Structure of PDB 8sfj Chain A Binding Site BS03

Receptor Information
>8sfj Chain A (length=1001) Species: 1111120 (Acidaminococcus sp. BV3L6) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTQFEGFTNLYQVSKTLRFELIPQGKTLKHIQEQGFIEEDKARNDHYKEL
KPIIDRIYKTYADQCLQLVQLDWENLSAAIDSYRKEKTEETRNALIEEQA
TYRNAIHDYFIGRTDNLTDAINKRHAEIYKGLFKAELFNGKVLKQLGTVT
TTEHENALLRSFDKFTTYFSGFYENRKNVFSAEDISTAIPHRIVQDNFPK
FKENCHIFTRLITAVPSLREHFENVKKAIGIFVSTSIEEVFSFPFYNQLL
TQTQIDLYNQLLGGIIKGLNEVLNLAIQKNDETAHIIASLPHRFIPLFKQ
ILSDRVEKFKLNFQMPTLASGWDVNKEKNNGAILFVKNGLYYLGIMPKQK
GRYKALSFEPTEKTSEGFDKMYYDYFPDAAKMIPKCSTQLKAVTAHFQTH
TTPILLSNNFIEPLEITKEIYDLNNPEKEPKKFQTAYAKKTGDQKGYREA
LCKWIDFTRDFLSKYTKTTSIDLSSLRPSSQYKDLGEYYAELNPLLYHIS
FQRIAEKEIMDAVETGKLYLFQIYNKDFAKGHHGKPNLHTLYWTGLFSPE
NLAKTSIKLNGQAELFYRPRFTSDKFFFHVPITLNYQAANSPSKFNQRVN
AYLKEHPETPIIGIDRGERNLIYITVIDSTGKILEQRSLNTIQQFDYQKK
LDNREKTIKDLKQGYLSQVIHEIVDLMIHYQAVVVLENLNFGFKSKRTGI
AEKAVYQQFEKMLIDKLNCLVLKDYPAEKVGGVLNPYQLTDQFTSFAKMG
TQSGFLFYVPAPYTSKIDPLTGFVDPFVWKTIKNHESRKHFLEGFDFLHY
DVKTGDFILHFKMNRNLSFQRGLPGFMPAWDIVFEKNETQFDAKGTPFIA
GKRIVPVIENHRFTGRYRDLYPANELIALLEEKGIVFRDGSNILPKLLEN
DDSHAIDTMVALIRSVLQMRNSNAATGEDYINSPVRDLNGVCFDSRFQNP
EWPMDADANGAYHIALKGQLLLNHLKESKDLKLQNGISNQDWLAYIQELR
N
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sfj WT CRISPR-Cas12a with a 10bp R-loop
Resolution3.6 Å
Binding residue
(original residue number in PDB)		Y83 E89 R92 K134 A135 K164 F165 T166 T167 Y575 D600 A602 K603 P606 K607 K653 Q656 T657 D706 S884 N996 F997 F999 K1054 R1168
Binding residue
(residue number reindexed from 1)		Y83 E89 R92 K134 A135 K164 F165 T166 T167 Y353 D378 A380 K381 P384 K385 K431 Q434 T435 D484 S591 N690 F691 F693 K748 R862
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004530 deoxyribonuclease I activity
GO:0016829 lyase activity
Biological Process
GO:0006259 DNA metabolic process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:8sfj, PDBe:8sfj, PDBj:8sfj
PDBsum8sfj
PubMed
UniProtU2UMQ6|CS12A_ACISB CRISPR-associated endonuclease Cas12a (Gene Name=cas12a)

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