Structure of PDB 8rqc Chain A Binding Site BS03

Receptor Information
>8rqc Chain A (length=300) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEEFRTLHDDDSIQVIPVLPQVMMILVPGQTLPLQLFHPQEVSMVRNLIQ
NDRTFAVLAYSNVQEAEFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKV
LELRTQSDGIQQAKVQILPEGSGDAETLMDRIKKQLREWDENLKDDSLPS
NPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLRCELDIMNKCTSLCCKQ
CQETEITTKNEIFSLSREGPMAAYVNPHGYVHEILTVYKACNLNLIGRPS
TEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALIPT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8rqc Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8rqc Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
Resolution2.15 Å
Binding residue
(original residue number in PDB)		C323 C326 C391 C394
Binding residue
(residue number reindexed from 1)		C198 C201 C266 C269
Annotation score4
External links
PDB RCSB:8rqc, PDBe:8rqc, PDBj:8rqc
PDBsum8rqc
PubMed
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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