Structure of PDB 8r3l Chain A Binding Site BS03

Receptor Information
>8r3l Chain A (length=708) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFASICTHLEVCFMYSD
FHFIDERGESTIILKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPD
LYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATK
ADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEIT
GTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIE
PFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAI
KCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIKNEEKIPRTK
NMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRSLACWIQ
SEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEY
IMKGVYINTALLNASCAAMDDFQLIPMISKCITKEGRRKTNLYGFIIKGR
SHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQVS
RPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDLT
KEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGF
SAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLLNASWFN
SFLTHALR
Ligand information
>8r3l Chain G (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
YSPTSPSYSPTSPSYSPTSPSYSP
Receptor-Ligand Complex Structure
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PDB8r3l The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		L288 K289 L290 T313 L417 A448 E449 R454 M548 L550 R551 F612 K635 R638
Binding residue
(residue number reindexed from 1)		L280 K281 L282 T305 L409 A440 E441 R446 M540 L542 R543 F604 K627 R630
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
GO:0075523 viral translational frameshifting
GO:0075526 cap snatching
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8r3l, PDBe:8r3l, PDBj:8r3l
PDBsum8r3l
PubMed38316757
UniProtM9TI86

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