Structure of PDB 8q41 Chain A Binding Site BS03

Receptor Information

>8q41 Chain A (length=427) Species: 509193 (Thermoanaerobacter brockii subsp. finnii Ako-1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EKVLVLIVGTNPLPNYVVGSHLKEKYDKFVLIYSEKNDKINQNSTYDYAK
KLKEHLNLNDKCIFLPLSDVSNSEKIINDLREKFPSEDFVEVHLNYTGGT
KTMVVHIYNFLKEKFIKFEGSYLDARDYKLVYDYSEEAISLKDTIKIDIN
TLLSIHLYEDIHFEFYDTYSYKQKFVDSFDKISQEIEKAIKDDKGEDFVK
WLEDPFRKIFKGENKLLEKTAKFKKHIEKLLSSPIVKFNEKTPQFIWDIL
NAFPEGKKLNDGQKLWIPDDKITNDNLSSRVKDTVEFLNGKWFEWYVYSQ
IKSELLDRKLKEGEHFGISLKAQKKDSPYFALDIFLINGYQLIGISLTTS
STRELCKLKGFEVIHRVRQIGGDESKAILITGMDKSKTEDLQKDLAYETG
STQKRFVVFGIDDWADIGSKICEEVFK

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

8q41 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8q41 Substrate selectivity and catalytic activation of the type III CRISPR-associated ancillary nuclease Can2
Resolution	2.38 Å
Binding residue (original residue number in PDB)	D343 L357
Binding residue (residue number reindexed from 1)	D333 L347
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:8q41, PDBe:8q41, PDBj:8q41
PDBsum	8q41
PubMed	38033326
UniProt	E8URK0

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