Structure of PDB 8q3b Chain A Binding Site BS03

Receptor Information
>8q3b Chain A (length=1423) Species: 10498 (African swine fever virus BA71V) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEAGYAEIAAVQFNIAGDNDHKRQGVMEVTISNLFEGTLPAEGGIYDARM
GTTDHHYKCITCSHQRKQCMGHPGILQMHAPVLQPLFIAEIRRWLRVICL
NCGAPIVDLKRYEHLIRPKRLIEAASSQTEGKQCYVCKAVHPKIVKDSED
YFTFWVDQQGKIDKLYPQIIREIFSRVTYDTVVKLGRSKNSHPEKLVLKA
IQIPPISIRPGIRLGSFHDINNVIQYLVRKNLLIPKDLQIVRGQKIPLNI
DRNLQTIQQLYYNFLLDSVSTRPAPSIMRRLPRKEGRIRKSLLGSQVWSI
SRSTICGNSDLHLDEVGYPISFARTLQVAETVQHYNINRLMPYFLNGKRQ
YPGCSRVYKQITQSVHDIEGLKQDFRLEVGDILYRDVVTGDVAFFNRQPS
LERSSIGVHRIVVLENPKISTFQMNVSACAWYNADFDGDQMNLWVPWSVM
SRVEAELLCSVRNWFISTKSSGPVNGQVQDSTVGSFLLTRTNTPMGKNVM
NKLHAMGLFQTTQTDPPCFANYSPTDLLDGKSVVSMLLKQTPINYQRAPT
WYSEVYAPYMHYNKQDISTQIRNGELIEGVLDKKAVGAGSSGGIYHLISR
RYGPQQALKMIFATQQLALNYVRNAGFTVSTADMLLTPEAHQEVQEIINK
LLLESEEINNRLLHGDIMPPIGLTTHDFYEKLQLNALKFPDRILKPIMNS
INPETNGLFQMVATGAKGSNPNMIHIMAGIGQIEINTQRIQPQFSFGRTL
VYYPRFALEAQAYGFICNSYIAGLTSPEFIFGEMNGRFDLINKALSTSST
GYANRKAIFGLQSCIVDYYRRVSIDTRLVQQLYGEDGLDARQLETVRFET
IMLSDQELEDKFKYTGIQSPLFEEEFSRLKKDRDKYRQIFLNVENFNFSQ
LLTDVRQVPVNVASIVKNILLSSTSGVLPFDEKSILQKYAMVKTFCKNLP
YVFINNIQERLQTPIPVYLKRAAALMRMLIRIELATVKTLNITCEQMSAI
LDLIRLQYTQSLINYGEAVGILAAQSVSEPLTQYMLDSHHRSVAGGTNKS
GIVRPQEIFSAKPVEAEQSSEMLLRLKNPEVETNKTYAQEIANSIELITF
ERLILQWHLLYETYSSTKKNVMYPDFASDVEWMTDFLENHPLLQPPEDIA
NWCIRLELNKTTMILKSISLESIINSLRAKHPNTYIMHSVENTASGIPII
IRIYLRESAFRRSTNTRMATDEKIAVNVVDKLLNSTIRGIPGIKNANVVK
LMRHRVDAQGKLVRLDNIYAIKTNGTNIFGAMLDDNIDPYTIVSSSIGDT
MELYGIEAARQKIISEIRTVMGDKGPNHRHLLMYADLMTRTGQVTSLEKA
GLNAREPSNVLLRMALSSPVQVLTDAAVDSAVNPIYGIAAPTLMGSVPRI
GTMYSDIIMDEKYITENYKSVDS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8q3b Chain A Residue 1503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8q3b Structural characterization of the fully recombinant RNA polymerase from African Swine Fever Virus
Resolution2.69 Å
Binding residue
(original residue number in PDB)		D457 D459 D461
Binding residue
(residue number reindexed from 1)		D435 D437 D439
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8q3b, PDBe:8q3b, PDBj:8q3b
PDBsum8q3b
PubMed38383525
UniProtP42486|RPB1_ASFB7 DNA-directed RNA polymerase RPB1 homolog (Gene Name=Ba71V-99)

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