Structure of PDB 8pzm Chain A Binding Site BS03

Receptor Information
>8pzm Chain A (length=499) Species: 652611 (Pseudomonas aeruginosa PA14) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FQGGMEFLVKSVRPETLKTATLVLAVGEGRKLGASAKAVDDATGGAISAV
LKRGDLAGKVGQTLLLQSLPNLKAERVLLVGAGKERELGDRQYRKLASAV
LSTLKGLAGADAALALGDLAVKGRGAHAKARLLVETLADGLYVFDRYKSQ
KAEPLKLKKLTLLADKADSAAVEQGSKEAQAIANGMALTRDLGNLPPNVC
HPTFLGEQAKGLAKEFKSLKVEVLDEKKLRELGMGSFLAVAQGSDQPPRL
IILQYNGAKKDQAPHVLVGKGITFDTGGISLKPGLGMDEMKFDMCGAASV
FGTFRAVLELQLPINLVGLLACAENMPSGGATRPGDIVTTMSGQTVEILN
TDAEGRLVLCDALTYAERFKPQSVIDIATLTGACIVALGSNTSGLMGNNE
ALVRQLLKAGEFADDRAWQLPLFDEYQEQLDSPFADIANIGGPKAGTITA
GCFLSRFAKKYHWAHLDIAGTAWISGGKDKGATGRPVPLLTQYLLERAK
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain8pzm Chain A Residue 605 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8pzm Unveiling the Catalytic Mechanism of a Processive Metalloaminopeptidase.
Resolution1.7 Å
Binding residue
(original residue number in PDB)
K287 D292 D310 E371
Binding residue
(residue number reindexed from 1)
K270 D275 D293 E354
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
3.4.11.10: bacterial leucyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019538 protein metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:8pzm, PDBe:8pzm, PDBj:8pzm
PDBsum8pzm
PubMed37924287
UniProtQ02RY8|AMPA_PSEAB Probable cytosol aminopeptidase (Gene Name=pepA)

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