Structure of PDB 8pm0 Chain A Binding Site BS03

Receptor Information

>8pm0 Chain A (length=708) Species: 1318616 (Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))

MEDFVRQCFNPMIVELAEKAMKEYGEDPKIETNKFASICTHLEVCFMYSD
FHFIDERGESTIILKHRFEIIEGRDRTMAWTVVNSICNTTGVEKPKFLPD
LYDYKENRFIEIGVTRREVHIYYLEKANKIKSEKTHIHIFSFTGEEMATK
ADYTLDEESRARIKTRLFTIRQEMASRGLWDSFRQSERGEETIEERFEIT
GTMRRLADQSLPPNFSSLENFRAYVDGFEPNGCIEGKLSQMSKEVNARIE
PFLRTTPRPLRLPDGPPCSQRSKFLLMDALKLSIEDPSHEGEGIPLYDAI
KCMKTFFGWKEPNIIKPHEKGINPNYLLTWKQVLAELQDIKNEEKIPRTK
NMKKTSQLKWALGENMAPEKVDFEDCKDVNDLKQYDSDEPEPRSLACWIQ
SEFNKACELTDSSWVELDEIGEDVAPIEHIASMRRNYFTAEVSHCRATEY
IMKGVYINTALLNASCAAMDDFQLIPMISKCITKEGRRKTNLYGFIIKGR
SHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRTAVGQVS
RPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDLT
KEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGF
SAESRKLLLIVQALRDNLEPGTFDLEGLYEAIEECLINDPWVLLNASWFN
SFLTHALR

Ligand information

>8pm0 Chain G (length=7) Species: 9606 (Homo sapiens)

YSPTSPS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8pm0 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): A448 E449 F612 K635 R638
• Binding residue (residue number reindexed from 1): A440 E441 F604 K627 R630

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication
• GO:0075523 viral translational frameshifting
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:8pm0, PDBe:8pm0, PDBj:8pm0
• PDBsum: 8pm0
• PubMed: 38316757
• UniProt: M9TI86