Structure of PDB 8peo Chain A Binding Site BS03

Receptor Information
>8peo Chain A (length=99) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKPHRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQ
SSAVMALQEASEAYLVALFEDTNLAAIHAKRVTIMPKDIQLARRIRGER
Ligand information
Ligand IDM2L
InChIInChI=1S/C7H16N2O2S/c1-9(2)3-4-12-5-6(8)7(10)11/h6H,3-5,8H2,1-2H3,(H,10,11)/t6-/m0/s1
InChIKeyXLXDHBGRMHYTIO-LURJTMIESA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CN(C)CCSCC(C(=O)O)N
CACTVS 3.341CN(C)CCSC[C@H](N)C(O)=O
ACDLabs 10.04O=C(O)C(N)CSCCN(C)C
OpenEye OEToolkits 1.5.0CN(C)CCSC[C@@H](C(=O)O)N
CACTVS 3.341CN(C)CCSC[CH](N)C(O)=O
FormulaC7 H16 N2 O2 S
Name(2R)-2-amino-3-(2-dimethylaminoethylsulfanyl)propanoic acid
ChEMBL
DrugBank
ZINC
PDB chain8peo Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8peo Multivalency of nucleosome recognition by LEDGF.
Resolution2.69 Å
Binding residue
(original residue number in PDB)		V35 K37
Binding residue
(residue number reindexed from 1)		V1 K2
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0046982 protein heterodimerization activity
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8peo, PDBe:8peo, PDBj:8peo
PDBsum8peo
PubMed37615563
UniProtP84233|H32_XENLA Histone H3.2

[Back to BioLiP]