Structure of PDB 8p4f Chain A Binding Site BS03

Receptor Information
>8p4f Chain A (length=1421) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEHGGCG
RYQPRIRRSGLELYAEWKKILLSPERVHEIFKRISDEECFVLGMEPRYAR
PEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNE
QNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLK
GKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIV
TPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGY
KVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNA
DFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTA
VRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSL
IIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKS
LGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIA
DSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRI
LNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVE
GKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGR
EGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGED
GLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLS
NAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIF
HINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIH
LRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQS
LGEPATQMKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKD
ILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVAR
ISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLV
LRIRIMNSDENKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDN
KKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIF
TVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITR
HGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPA
GTGCFDLLLDAEKCKYGMEIP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p4f Structural insights into human co-transcriptional capping.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		P323 K346 R358 Q461 Y859 R1416 E1433
Binding residue
(residue number reindexed from 1)		P279 K302 R314 Q417 Y815 R1350 E1367
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p4f, PDBe:8p4f, PDBj:8p4f
PDBsum8p4f
PubMed37369200
UniProtA0A8D1DPV6

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