Structure of PDB 8p2i Chain A Binding Site BS03

Receptor Information
>8p2i Chain A (length=901) Species: 186497 (Pyrococcus furiosus DSM 3638) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKKVIGSIEFGILSPQEIRKMSAVEVTVPDTYDDDGYPIEGGVMDKRMGV
IDPGLRCETCGGRAGECPGHFGHIELARPVIHVGFAKTIYRILESTCREC
GRIKLTDEEIEEYMKKIELARNRRSEFNEIIKEIHKKAKERMVCPHCGAP
QYPIKFEKPTIYWEIRKDEQGNEYRHRLMPTEVRDWLEKIPDKDLPLLGL
DPEKSRPEWMVLTVLPVPPVTARPSITLETGIRAEDDLTHKLVDIIRINN
RLKQNIEAGAPQLIIEDLWDLLQYHVTTYINNEAPGVPPAKHKSGRPLKT
LAQRLKGKEGRFRGNLSGKRVNFSARTVISPDPMISINEVGVPVEVAMEL
TVPEKVTEFNIERLRKMVLNGPDKYPGANYVIDPEGRRRRIMDSNKETLA
NQLDIGWTVERHLMDGDIVLFNRQPSLHRMSIMAHRVRVMPYRTFRLNLA
VCPPYNADFDGDEMNLHVPQTEEAQAEARILMEVQNHIISPRYGGPIIGG
IQDHISGGYLLTREGAYFTRDEVEQMLMFAGVDITELPEPDKYDENGNPL
WSGKTIFSLLLPEDLTVWYRNKLCDEPERCEALEKLIEEKLMPDPEEVRK
LAYDGFVYIQNGKLLSGAIDKKAYGREDGIILDLIVREYGVERARQFLDQ
VTKLTIWVITHKGFTTGIDDEDLPEEARDRIREIIREAEERVNKLIEAYK
RGELEPLPGKSLEDTLESLIMAVLAEARDNAGAVAEKYLGMDNHTVIMAK
TGARGKILNITQMAALLGQQSIRGKRLYRGFRGRVLSHFKPGDLGARAKG
FVVNSYKSGLTPQEYFFHAMGGREGLVDTAVRTAQSGYMQRRLINALQDL
KVEYDGTVRSPEGIIVQFKYGEDGVDPMKSWRGKTVDVDRIIVRTLLKMR
G
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8p2i Chain A Residue 1002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8p2i Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment
Resolution3.4 Å
Binding residue
(original residue number in PDB)		D458 D460 D462
Binding residue
(residue number reindexed from 1)		D458 D460 D462
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8p2i, PDBe:8p2i, PDBj:8p2i
PDBsum8p2i
PubMed38709902
UniProtQ8U0M4

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