Structure of PDB 8p0n Chain A Binding Site BS03

Receptor Information
>8p0n Chain A (length=1277) Species: 10245 (Vaccinia virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVISKVTYSLYDQKEINATDIIISHVKNDDDIGTVKDGRLGAMDGALCKT
CGKTELECFGHWGKVSIYKTHIVKPEFISEIIRLLNHICIHCGLLRSREP
YSDDINLKELSGHALRRLKDKILSKKKSCWNSECMQPYQKITFSKKKVCF
VNKLDDINVPNSLIYQKLISIHEKFWPLLEIHQYPANLFYTDYFPIPPLI
IRPAISETNELTYLLGMIVKNCNLNADEQVIQKAVIEYDDIKIISNNTTS
INLSYITSGKNNMIRSYIVARRKDQTARSVIGPSTSITVNEVGMPAYIRN
TLTEKIFVNAFTVDKVKQLLASNQVKFYFNKRLNQLTRIRQGKFIKNKIH
LLPGDWVEVAVQEYTSIIFGRQPSLHRYNVIASSIRATEGDTIKISPGIA
NSQNADFDGDEEWMILEQNPKAVIEQSILMYPTTLLKHDIHGAPVYGSIQ
DEIVAAYSLFRIQDLCLDEVLNILGKYGREFDPKGKCKFSGKDIYTYLIG
EKINYPGLLKDGEIIANDVDSNFVVAMRHLSLAGLLSDHKSNVEGINFII
KSSYVFKRYLSIYGFGVTFKDLRPNSTFTNKLEAINVEKIELIKEAYAKY
LNDVRDGKIVPLSKALEADYVESMLSNLTNLNIREIEEHMRQTLIDDPDN
NLLKMAKAGYKVNPTELMYILGTYGQQRIDGEPAETRVLGRVLPYYLPDS
KDPEGRGYILNSLTKGLTGSQYYFSMLVARSQSTDIVCETSRTGTLARKI
IKKMEDMVVDGYGQVVIGNTLIKYAANYTKILGSVCKPVDLIYPDESMTW
YLEISALWNKIKQGFVYSQKQKLAKKTLAPFNFLVFVKPTTEDNAIKVKD
LYDMIHNVIDDVREKYFFTVSNIDFMEYIFLTHLNPSRIRITKETAITIF
EKFYEKLNYTLGGGTPIGIISAQVLSEKFTQQALSSFHTTEKSGAVKQKL
GFNEFNNLTNLSKNKTEIITLVSDDISKLQSVKINFEFVCLGELNPNITL
RKETDKYVVDIIVNRLYIKRAEITELVVEYMIERFISFSVIVKEWGMETF
IEDEDNIRFTVYLNFVEPEELNLSKFMMVLPGAANKGKISKFKIPISDYT
GYDDFNQTKKLNKMTVELMNLKELGSFDLENVNVYPGVWNTYDIFGIEAA
REYLCEAMLNTYGEGFDYLYQPCDLLASLLCASYEPESVNKFKFGAASTL
KRATFGDNKALLNAALHKKSEPINDNSSCHFFSKVPNIGTGYYKYFIDLG
LLMRMERKLSDKISSQKIKEMEETEDF
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain8p0n Chain A Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p0n Cryo EM map and model of the vaccinia RNA polymerase intermediate pre-initiation open promoter complex (CASP target)
Resolution2.58 Å
Binding residue
(original residue number in PDB)		D415 D417 D419
Binding residue
(residue number reindexed from 1)		D406 D408 D410
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:8p0n, PDBe:8p0n, PDBj:8p0n
PDBsum8p0n
PubMed
UniProtP20504|RP147_VACCC DNA-directed RNA polymerase 147 kDa polypeptide (Gene Name=OPG105)

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