Structure of PDB 8omr Chain A Binding Site BS03

Receptor Information
>8omr Chain A (length=390) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PRIMRLVAECSRSRARAGELWLPHGTVATPVFMPVGTQATMKGITTEQLD
ALGCRICLGNTYHLGLRPGPELIQKANGLHGFMNWPHNLLTDSGGFQMVS
LVSLSEVTEEGVRFRSPYDGNETLLSPEKSVQIQNALGSDIIMQLDDVVS
STVTGPRVEEAMYRSIRWLDRCIAAHQRPDKQNLFAIIQGGLDADLRATC
LEEMTKRDVPGFAIGGLSGGESKSQFWRMVALSTSRLPKDKPRYLMGVGY
ATDLVVCVALGCDMFDCVFPTRTARFGSALVPTGNLQLRKKVFEKDFGPI
DPECTCPTCQKHSRAFLHALLHSDNTAALHHLTVHNIAYQLQLMSAVRTS
IVEKRFPDFVRDFMGAMYGDPTLCPTWATDALASVGITLG
Ligand information
Ligand ID9DG
InChIInChI=1S/C6H6N4O/c7-6-9-3-1-2-8-4(3)5(11)10-6/h1-2,8H,(H3,7,9,10,11)
InChIKeyFFYPRJYSJODFFD-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341NC1=Nc2cc[nH]c2C(=O)N1
OpenEye OEToolkits 1.5.0c1c[nH]c2c1N=C(NC2=O)N
ACDLabs 10.04O=C1c2c(N=C(N1)N)ccn2
FormulaC6 H6 N4 O
Name9-DEAZAGUANINE
ChEMBLCHEMBL367746
DrugBankDB04356
ZINCZINC000100004977
PDB chain8omr Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8omr Novel structural and functional insights into human tRNA guanine transglycosylase
Resolution3.3 Å
Binding residue
(original residue number in PDB)		D105 D159
Binding residue
(residue number reindexed from 1)		D92 D146
Annotation score2
Enzymatic activity
Enzyme Commision number 2.4.2.64: tRNA-guanosine(34) queuine transglycosylase.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008479 tRNA-guanosine(34) queuine transglycosylase activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0101030 tRNA-guanine transglycosylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0032473 cytoplasmic side of mitochondrial outer membrane
GO:0032991 protein-containing complex
GO:0120507 tRNA-guanine transglycosylase complex
GO:1990234 transferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8omr, PDBe:8omr, PDBj:8omr
PDBsum8omr
PubMed38181786
UniProtQ9BXR0|TGT_HUMAN Queuine tRNA-ribosyltransferase catalytic subunit 1 (Gene Name=QTRT1)

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