Structure of PDB 8kho Chain A Binding Site BS03

Receptor Information
>8kho Chain A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SHSIVLPAAVSSAHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLH
QACQLARHVLLLAGKSLKVDMTTEEIDALVHREIISHNAYPSPLGYGGFP
KSVCTSVNNVLCHGIPDSRPLQDGDIINIDVTVYYNGYHGDTSETFLVGN
VDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQNGFQVCPH
FVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLE
DAWTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain8kho Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8kho Structural insights into N-terminal methionine cleavage by the human mitochondrial methionine aminopeptidase, MetAP1D.
Resolution1.45 Å
Binding residue
(original residue number in PDB)		D178 D189 E315
Binding residue
(residue number reindexed from 1)		D130 D141 E267
Annotation score3
Enzymatic activity
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:8kho, PDBe:8kho, PDBj:8kho
PDBsum8kho
PubMed38102161
UniProtQ6UB28|MAP12_HUMAN Methionine aminopeptidase 1D, mitochondrial (Gene Name=METAP1D)

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