Structure of PDB 8jx8 Chain A Binding Site BS03

Receptor Information

>8jx8 Chain A (length=1436) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CPTQPFHCPSTQWQCPGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCS
HFNGGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHC
VNMRGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNITAH
THNLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVH
DSGLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKP
RGLALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLS
IDYPNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDF
VYWTDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPC
ASASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDN
IIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRV
KTDGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDT
RYGKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASAN
MDGTSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERM
ILVHHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYL
RGLRVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPD
GRSCSPYNSFMVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDV
ANGFIYWCDFSSSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDW
AAGNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYL
FWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDS
LDLIARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQAS
KQPGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCS
HFCFALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFD
PRDHSLPFQVISVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSG
SSSPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIA
RVSKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPN
GLALDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHSFGLTVYGQY
IYWTDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSNP
CDQFNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQ
FTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHT

Ligand information

>8jx8 Chain L (length=5) Species: 10116 (Rattus norvegicus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

AANAA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8jx8 Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Resolution	3.3 Å
Binding residue (original residue number in PDB)	R2511 W2527 W2553 N2555 H2595
Binding residue (residue number reindexed from 1)	R1206 W1222 W1248 N1250 H1290

External links

PDB	RCSB:8jx8, PDBe:8jx8, PDBj:8jx8
PDBsum	8jx8
PubMed	38771880
UniProt	P98158\|LRP2_RAT Low-density lipoprotein receptor-related protein 2 (Gene Name=Lrp2)

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