Structure of PDB 8jds Chain A Binding Site BS03

Receptor Information
>8jds Chain A (length=456) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSQDFVEALKAVVGSPHVSTASAVREQHGHDESMHRCQPPDAVVWPQNVD
QVSRVASLCYNQGVPIIPFGTGTGVEGGVCAVQGGVCINLTHMDQITELN
TEDFSVVVEPGVTRKALNTHLRDSGLWFPVDPGADASLCGMAATGASGTN
AVRYGTMRDNVINLEVVLPDGRLLHTAGRGRHYRKSAAGYNLTGLFVGSE
GTLGIITSTTLRLHPAPEATVAATCAFPSVQAAVDSTVQILQAAVPVARI
EFLDDVMMDACNRHSKLNCPVAPTLFLEFHGSQQTLAEQLQRTEAITQDN
GGSHFSWAAEKRNELWAARHNAWYAALALSPGSKAYSTDVCVPISRLPEI
LVETKEEIKASKLTGAIVGHVGDGNFHCILLVDPDDAEEQRRVKAFAENL
GRRALALGGTCTGEHGIGLGKRQLLQEEVGPVGVETMRQLKNTLDPRGLM
NPGKVL
Ligand information
Ligand IDPYR
InChIInChI=1S/C3H4O3/c1-2(4)3(5)6/h1H3,(H,5,6)
InChIKeyLCTONWCANYUPML-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CC(=O)C(O)=O
OpenEye OEToolkits 1.7.6CC(=O)C(=O)O
ACDLabs 12.01O=C(C(=O)O)C
FormulaC3 H4 O3
NamePYRUVIC ACID
ChEMBLCHEMBL1162144
DrugBankDB00119
ZINCZINC000001532517
PDB chain8jds Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8jds Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids containing hydrophobic moieties and plays an important role in the pathogenesis of D-lactic acidosis
Resolution1.636 Å
Binding residue
(original residue number in PDB)		R347 H398 H405 H443
Binding residue
(residue number reindexed from 1)		R319 H370 H377 H415
Annotation score5
Enzymatic activity
Enzyme Commision number 1.1.2.4: D-lactate dehydrogenase (cytochrome).
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004458 D-lactate dehydrogenase (cytochrome) activity
GO:0005515 protein binding
GO:0008720 D-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0006754 ATP biosynthetic process
GO:1903457 lactate catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jds, PDBe:8jds, PDBj:8jds
PDBsum8jds
PubMed37863926
UniProtQ7TNG8|LDHD_MOUSE Probable D-lactate dehydrogenase, mitochondrial (Gene Name=Ldhd)

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