Structure of PDB 8jde Chain A Binding Site BS03

Receptor Information
>8jde Chain A (length=455) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSQDFVEALKAVVGSPHVSTASAVREQHGHDESMHRCQPPDAVVWPQNVD
QVSRVASLCYNQGVPIIPFGTGTGVEGGVCAVQGGVCINLTHMDQITELN
TEDFSVVVEPGVTRKALNTHLRDSGLWFPVDPGADASLCGMAATGASGTN
AVRYGTMRDNVINLEVVLPDGRLLHTAGRGRHYRKSAAGYNLTGLFVGSE
GTLGIITSTTLRLHPAPEATVAATCAFPSVQAAVDSTVQILQAAVPVARI
EFLDDVMMDACNRHSKLNCPVAPTLFLEFHGSQQTLAEQLQRTEAITQDN
GGSHFSWAAEKNELWAARHNAWYAALALSPGSKAYSTDVCVPISRLPEIL
VETKEEIKASKLTGAIVGHVGDGNFHCILLVDPDDAEEQRRVKAFAENLG
RRALALGGTCTGEHGIGLGKRQLLQEEVGPVGVETMRQLKNTLDPRGLMN
PGKVL
Ligand information
Ligand IDLAC
InChIInChI=1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1
InChIKeyJVTAAEKCZFNVCJ-UWTATZPHSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)C(O)C
CACTVS 3.341C[CH](O)C(O)=O
OpenEye OEToolkits 1.5.0C[C@H](C(=O)O)O
CACTVS 3.341C[C@@H](O)C(O)=O
OpenEye OEToolkits 1.5.0CC(C(=O)O)O
FormulaC3 H6 O3
NameLACTIC ACID
ChEMBLCHEMBL358850
DrugBankDB03066
ZINCZINC000004658562
PDB chain8jde Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8jde Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids containing hydrophobic moieties and plays an important role in the pathogenesis of D-lactic acidosis
Resolution1.729 Å
Binding residue
(original residue number in PDB)		R347 H398 H405 H443
Binding residue
(residue number reindexed from 1)		R318 H369 H376 H414
Annotation score5
Enzymatic activity
Enzyme Commision number 1.1.2.4: D-lactate dehydrogenase (cytochrome).
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004458 D-lactate dehydrogenase (cytochrome) activity
GO:0005515 protein binding
GO:0008720 D-lactate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0006754 ATP biosynthetic process
GO:1903457 lactate catabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8jde, PDBe:8jde, PDBj:8jde
PDBsum8jde
PubMed37863926
UniProtQ7TNG8|LDHD_MOUSE Probable D-lactate dehydrogenase, mitochondrial (Gene Name=Ldhd)

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