Structure of PDB 8j0r Chain A Binding Site BS03

Receptor Information
>8j0r Chain A (length=215) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGV
LRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLAR
DFGYVCETEFPAKAVAEFLNRQHSDPNEQVTRKNMLLATKQICKEFTDLL
AQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYL
TEALKAMDKMYLSNN
Ligand information
Ligand IDPG3
InChIInChI=1S/C4H11N3O/c5-4(6)7-2-1-3-8/h8H,1-3H2,(H4,5,6,7)/p+1
InChIKeyJDXXTKLHHZMVIO-UHFFFAOYSA-O
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CNC(=[NH2+])N)CO
CACTVS 3.341NC(=[NH2+])NCCCO
ACDLabs 10.04OCCCNC(=[NH2+])\N
FormulaC4 H12 N3 O
NameGUANIDINE-3-PROPANOL
ChEMBL
DrugBankDB03637
ZINC
PDB chain8j0r Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8j0r Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		E242 C243 R281 A283
Binding residue
(residue number reindexed from 1)		E40 C41 R79 A81
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8j0r, PDBe:8j0r, PDBj:8j0r
PDBsum8j0r
PubMed37409559
UniProtP05549|AP2A_HUMAN Transcription factor AP-2-alpha (Gene Name=TFAP2A)

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