Structure of PDB 8i9o Chain A Binding Site BS03

Receptor Information
>8i9o Chain A (length=526) Species: 866768 (Escherichia coli 'BL21-Gold(DE3)pLysS AG') [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTIMKLDPYINVDPGT
MSPIQHGEVFVTEDGAETDLDLGHYERFIRTKMSRRNNFTTGRIYSDVLR
KERRGDYLGATVQVIPHITNAIKERVLEGGEGHDVVLVEIGGTVGDIESL
PFLEAIRQMAVEIGREHTLFMHLTLVPYMAASGEVKTKPTQHSVKELLSI
GIQPDILICRSDRAVPANERAKIALFCNVPEKAVISLKDVDSIYKIPGLL
KSQGLDDYICKRFSLNCPEANLSEWEQVIFEEANPVSEVTIGMVGKYIEL
PDAYKSVIEALKHGGLKNRVSVNIKLIDSQDVETRGVEILKGLDAILVPG
GFGYRGVEGMITTARFARENNIPYLGICLGMQVALIDYARHVANMENANS
TEFVPDCKYPVVALITEWRTMRLGAQQCQLVDDSLVRQLYNAPTIVERHR
HRYEVNNMLLKQIEDAGLRVAGRSGDDQLVEIIEVPNHPWFVACQFHPEF
TSTPRDGHPLFAGFVKAASEFQKRQA
Ligand information
Ligand IDCTP
InChIInChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1
InChIKeyPCDQPRRSZKQHHS-XVFCMESISA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O
OpenEye OEToolkits 1.5.0C1=CN(C(=O)N=C1N)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O
CACTVS 3.341NC1=NC(=O)N(C=C1)[CH]2O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]2O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC2OC(N1C(=O)N=C(N)C=C1)C(O)C2O
CACTVS 3.341NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO[P@@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]2O
FormulaC9 H16 N3 O14 P3
NameCYTIDINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL223533
DrugBankDB02431
ZINCZINC000003861746
PDB chain8i9o Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8i9o Filamentation and inhibition of prokaryotic CTP synthase
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K187 T188 K189 K223 F227
Binding residue
(residue number reindexed from 1)		K186 T187 K188 K222 F226
Annotation score4
Enzymatic activity
Enzyme Commision number 6.3.4.2: CTP synthase (glutamine hydrolyzing).
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003883 CTP synthase activity
GO:0004359 glutaminase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006541 glutamine metabolic process
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0044210 'de novo' CTP biosynthetic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0097268 cytoophidium

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8i9o, PDBe:8i9o, PDBj:8i9o
PDBsum8i9o
PubMed38948148
UniProtP0A7E5|PYRG_ECOLI CTP synthase (Gene Name=pyrG)

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