Structure of PDB 8i4d Chain A Binding Site BS03

Receptor Information

>8i4d Chain A (length=419) Species: 5507 (Fusarium oxysporum)

LTVKSTKQWTIGTDVQGSERLNGVSYQEDALITYGDYQYVTFYETAPAGY
LNHFVKVGRRRVSPSVGDWEFLTLDDYTQKTMDGHNMISMGISGDGKIHL
SFDHHDVPINYRISKNGIAKDVPSKWTSDLFDPVVHELVGSQGPYSPLTY
PRFEPLGNGDLLLEFRIGQSGSGDSYIHRYSASTGKWQAYGMYIQGDDNN
AYINGLDYLDGKLYTSWTVRETPNADTNHGVYFAYSNDDGKTWFNTNDTK
LTKPISTSDDSTLIWDIPQNSRMVNQEGQLIDTKGRFHILMRDLLSGEHQ
YQHYLRKADGTWTKNAINPAGLNGPDLYDPRGKLAGDASGEYLFGILPDP
VKQSTGIYVATASKDFKDWKSLAEIPNTSTEPLFDKTRLHESGILSVFVR
QAGGFPDRKLQVWDFELDL

Ligand information

• Ligand ID: RAM
• InChI: InChI=1S/C6H12O5/c1-2-3(7)4(8)5(9)6(10)11-2/h2-10H,1H3/t2-,3-,4+,5+,6+/m0/s1
• InChIKey: SHZGCJCMOBCMKK-HGVZOGFYSA-N
• SMILES:
  CACTVS 3.341: C[C@@H]1O[C@@H](O)[C@H](O)[C@H](O)[C@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)C
  OpenEye OEToolkits 1.5.0: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O)O)O)O
  OpenEye OEToolkits 1.5.0: CC1C(C(C(C(O1)O)O)O)O
  CACTVS 3.341: C[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
• Formula: C6 H12 O5
• Name: alpha-L-rhamnopyranose;
  alpha-L-rhamnose;
  6-deoxy-alpha-L-mannopyranose;
  L-rhamnose;
  rhamnose
• ZINC: ZINC000003861280
• PDB chain: 8i4d Chain A Residue 601

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8i4d Charge neutralization and beta-elimination cleavage mechanism of family 42 L-rhamnose-alpha-1,4-D-glucuronate lyase revealed using neutron crystallography
• Resolution: 1.06 Å
• Binding residue (original residue number in PDB): Y26 H85 Y150 N275 Q276 R331
• Binding residue (residue number reindexed from 1): Y26 H85 Y150 N275 Q276 R331
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 4.2.2.-

Gene Ontology

Molecular Function

• GO:0046872 metal ion binding

External links

• PDB: RCSB:8i4d, PDBe:8i4d, PDBj:8i4d
• PDBsum: 8i4d
• PubMed: 38382672
• UniProt: A0A8J0PCK3