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Receptor Information

>8hnw Chain A (length=809) Species: 729 (Haemophilus parainfluenzae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ILGLDLGIASVGWAVVEIDEKENPLRLIDVGVRTFEGESLALSRRLARSA
RRLTQRRVARLKKAKRLLKSENILLSTDERLPHQVWQLRVEGLDHKLERQ
EWAAVLLHLIKHRGYLSQRKNESKELGALLSGVDNNHKLLQQATYRSPAE
LAVKKFEVEEGHIRNQQGAYTHTFSRLDLLAEMELLFSRQQHFGNPFASE
KLLENLTALLMWQKPALSGEAILKMLGKFEDEYKAAKNTYSAERFVWITK
LNNLRIQENGLERALNDNERLALMEQPYDKNRLFYSQVRSILKLSDIFKG
LRIETKAVLMEMKAYHQIRKVLEGNNLKAEWAELKANPTLLDEIGTAFSL
YKTDEDISAYLAGKLSQPVLNALLENLSFDKFIQLSLKALYKLLPLMQQG
LRYDEACREIYFLPQIPADEIRNPVVLRTLTQARKVINGVVRLYGSPARI
HIETRNLNDTRYVARFLCNFIADNMHLVFASNGQITALLNDRHHALDAVV
VACSTVAMQQKITRFLHFPTPWQFFKQEVEIRIFSDNPKLELENRLPDRP
QANHEFVQPLFVSRMPTRKMTGQGHMETVKSAKRLNEGISVIKMPLTKLK
LKDLELMVNREREKDLYDTLKARLEAFNDDPAKAFAEPFIKKGGAIVKSV
RVEQIQKSGVLVREGNGVADNASMVRVDVFTKGGKYFLVPIYTWQVAKGI
LPNKAATQYKDEEDWEVMDNSATFKFSLHPNDLVKLVTKKKTILGYFNGL
NRATGNIDIKEHDLDKSKGKQGIFEGVGIKLALSFEKYQVDELGKNIRLC
KPSKRQPVR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8hnw AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.
Resolution	3.41 Å
Binding residue (original residue number in PDB)	S903 N916 A917 M919 Y937 N996 R997 A998
Binding residue (residue number reindexed from 1)	S658 N671 A672 M674 Y692 N751 R752 A753

Enzyme Commision number

3.1.-.-

	Molecular Function
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0004519	endonuclease activity
GO:0046872	metal ion binding

	Biological Process
GO:0043571	maintenance of CRISPR repeat elements
GO:0051607	defense response to virus

PDB	RCSB:8hnw, PDBe:8hnw, PDBj:8hnw
PDBsum	8hnw
PubMed	37494395
UniProt	F0ET08

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Structure of PDB 8hnw Chain A Binding Site BS03