Structure of PDB 8gu6 Chain A Binding Site BS03

Receptor Information
>8gu6 Chain A (length=1211) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGRTAGKSF
ITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSFLRK
RHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFSNFD
LDHDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGTYTGRITLR
NEHAKKLLLASLGFVDKLCGALCRIEVIHNDELRKQAEVIVEAFKQNDKL
EKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHHLWDIKVQGTALR
TKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETGGTEYYSSDLFIPVTP
PEGIETKEWIIVGRLKAATPFYFGVQQPSDSIPGEHTSFNILLDKENRYR
IPRSALRGALRRDLRTAFGSGCNVSLGGQILCNCKVCIEMRRITLKDSVS
DFSEPPEIRYRIAKNPGTATVEDGSLFDIEVGPEGLTFPFVLRYRGHKFP
EQLSSVIRYWEENDGKNGMAWLGGLDSTGKGRFALKDIKIFEWDLNQKIN
EYIKERGMRGKEKELLEMLPDGLIPYKFFEERECLFPYKENLKPQWSEVQ
YTIEVGSPLLTADTISALTEPGNRDAIAYKKRVYNDGNNAIEPEPRFAVK
SETHRGIFRTAVGRRTGDLGKEDHEDCTCDMCIIFGNEHESSKIRFEDLE
LINGNEFEKLEKHIDHVAIDRFTGGALDKAKFDTYPLAGSPKKPLKLKGR
FWIKKGFSGDHKLLITTALSDIRDGLYPLGSKGGVGYGWVAGISIDDNVP
DDFKEMINKINNDYVHPGHQSPKQDNIYYPHYFLDSGSKVYREKDIITHE
EFTEELLSGKINCKLETLTPLIIPDTSDENGLKLQGNKPGHKNYKFFNIN
GELMIPGSELRGMLRTHFEALTKSCFAIFGEDSTKTLGGKLDKALHPCTG
LSDGLCPGCHLFGTTDYKGRVKFGFAKYENGPEWLITRGNNPERSLTLGV
LESPRPAFSIPDDESEIPGRKFYLHHNGWRIIRQKQLEIRETVQPERNVT
TEVMDKGNVFSFDVRFENLREWELGLLLQSLDPGKNIAHKLGKGKPYGFG
SVKIKIDSLHTFKIKRVPQSDIREYINKGYQKLIEWLPQWHVIPHIDKLY
KLLWVPFLLEPDVRYPVLNEESKGYIEGSDYTYKKLGDKDNLPYKTRVKG
LTTPWSPWNPF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8gu6 Chain A Residue 1801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gu6 Target RNA-guided protease activity in type III-E CRISPR-Cas system.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		C491 C501 C503 C506
Binding residue
(residue number reindexed from 1)		C422 C432 C434 C437
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8gu6, PDBe:8gu6, PDBj:8gu6
PDBsum8gu6
PubMed36484100
UniProtA0A0B0EGF3

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