Structure of PDB 8gm5 Chain A Binding Site BS03

Receptor Information
>8gm5 Chain A (length=479) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDE
VLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDR
DVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHL
EHYIEGKYIKYNSNSGFVRDNIRLTPQAFSHFTFERSGHQLIVVDIQGVG
DLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLS
PRERDAVNQNQSAKTILRGTEEKCRASAVALEVQRLLEKKIGKSILGKVH
LAMVRYHEGGRFCEEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPH
HILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPD
RCQDWLEALHWYNTALEMEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLY
TQAAEAAMEAMKGRLANQYYQKAEEAWAQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8gm5 Chain A Residue 803 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gm5 Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
Resolution2.12 Å
Binding residue
(original residue number in PDB)		H260 H312 C314 C318
Binding residue
(residue number reindexed from 1)		H181 H233 C235 C239
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.20: [elongation factor 2] kinase.
Gene Ontology
Molecular Function
GO:0004674 protein serine/threonine kinase activity
GO:0004686 elongation factor-2 kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:8gm5, PDBe:8gm5, PDBj:8gm5
PDBsum8gm5
PubMed37172726
UniProtO00418|EF2K_HUMAN Eukaryotic elongation factor 2 kinase (Gene Name=EEF2K)

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