Structure of PDB 8fdb Chain A Binding Site BS03

Receptor Information

>8fdb Chain A (length=332) Species: 318161 (Shewanella denitrificans OS217)

TTNTIMEQEARTAPQKIAEQLLANDAITESLGSVLREFKPKFVMIVGRGS
SDHAGVFAKYLFEIEASIPTFAAAPSVASVYGKTLKLAGGLVIVISQSGR
SPDILAQARMAKNAGAFCVALVNDETAPIKDIVDVVIPLRAGEEKAVAAT
KSYLATLSALLQVAAKWTQNESLVEAVNSLPQALQAAVDAEPQLRAGSLT
DVKNLVVLGRGFGYAVSKEIALKLKEVCAIHAEAFSSAEFLHGPVTLVEK
KLSILDVCIRDESYGSHVEQIANVKQRGANLIHLHQTSADIHPRIAPLAL
LQRFYIDVAAVAIALGINPDKPAGLKKVTQTL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8fdb Chain A Residue 503

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8fdb Substrate binding in the allosteric site mimics homotropic cooperativity in the SIS-fold glucosamine-6-phosphate deaminases.
• Resolution: 3.06 Å
• Binding residue (original residue number in PDB): G48 R49 I96 S97
• Binding residue (residue number reindexed from 1): G47 R48 I95 S96
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.6.1.16: glutamine--fructose-6-phosphate transaminase (isomerizing).

Gene Ontology

Molecular Function

• GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
• GO:0008483 transaminase activity
• GO:0097367 carbohydrate derivative binding

Biological Process

• GO:1901135 carbohydrate derivative metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:8fdb, PDBe:8fdb, PDBj:8fdb
• PDBsum: 8fdb
• PubMed: 37145875
• UniProt: Q12KP2