Structure of PDB 8eii Chain A Binding Site BS03

Receptor Information

>8eii Chain A (length=431) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DQSREQMASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFL
ELFYMYDDDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGTGTA
AEAKLQEPWSCYMCLPQRCHGVLRRRKDWNVRLQAFFTSDTGLEYEAPKL
YPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGKYVASEVCEESIAV
GTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPARKG
LYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRF
LECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYN
RIAKLKKVQTITTKSLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMG
RGARQKLLGRSWSVPVIRHLFAPLKDYFACE

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8eii Chain A Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8eii Cryo-EM structure of human DNMT3B homo-tetramer (form II)
Resolution	3.12 Å
Binding residue (original residue number in PDB)	C478 C481 C500
Binding residue (residue number reindexed from 1)	C65 C68 C87
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.1.1.37: DNA (cytosine-5-)-methyltransferase.

Gene Ontology

	Molecular Function
GO:0008168	methyltransferase activity
GO:0009008	DNA-methyltransferase activity

	Biological Process
GO:0010468	regulation of gene expression

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Molecular Function

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Biological Process

External links

PDB	RCSB:8eii, PDBe:8eii, PDBj:8eii
PDBsum	8eii
PubMed	37941146
UniProt	Q9UBC3\|DNM3B_HUMAN DNA (cytosine-5)-methyltransferase 3B (Gene Name=DNMT3B)

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