Structure of PDB 8eex Chain A Binding Site BS03

Receptor Information
>8eex Chain A (length=1284) Species: 45657 (Desulfonema ishimotonii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MTTTMKISIEFLEPFRMTKWQESTRRNKNNKEFVRGQAFARWHRNKKDNT
KGRPYITGTLLRSAVIRSAENLLTLSDGKISEKTCCPGKFDTEDKDRLLQ
LRQRSTLRWTDKNPCPDNAETYCPFCELLGRSGNDWRFRIHFGNLSLPGK
PDFDGPKAIGSQRVLNRVDFKSGKAHDFFKAYEVDHTRFPRFEGEITIDN
KVSAEARKLLCDSLKFTDRLCGALCVIRFNLAEKTAEQIISILDDNKKTE
YTRLLADAIRSLRRSSKLVAGLPKDHDGKDDHYLWDIGKVTIRQILTTSA
DTKELKNAGKWREFCEKLGEALYLKSKDMSGGLKITRRILGDAEFHGKPD
RLEKSRSVSIGSVLKETVVCGELVAKTPFFFGAIDEDAKQTALQVLLTPD
NKYRLPRSAVRGILRRDLQTYFDSPCNAELGGRPCMCKTCRIMRGITVMD
ARSEYNAPPEIRHRTRINPFTGTVAEGALFNMEVAPEGIVFPFQLRYRGS
EDGLPDALKTVLKWWAEGQAFMSGAASTGKGRFRMENAKYETLDLSDENQ
RNDYLKNWGWRDEKGLEELKKRLNSGLPEPGNYRDPKWHEINVSIEMASP
FINGDPIRAAVDKRGTAVVTFVKYKAEGEEAKPVCAYKAESFRGVIRSAV
ARIHMEDGVPLTELTHSDCECLLCQIFGSEYEAGKIRFEDLVFESDPEPV
TFDHVAIDRFTGGAADKKKFDDSPLPGSPARPLMLKGSFWIRRDVLEDEE
YCKALGKALADVNNGLYPLGGKSAIGYGQVKSLGIKGDDKRISRLMNPAF
DETDVAVPEKPKTDAEVRIEAEKVYYPHYFVEPHKKVEREEKPCGHQKFH
EGRLTGKIRCKLITKTPLIVPDTSNDDFFRPADKEARKEKDEYHKSYAFF
RLHKQIMIPGSELRGMVSSVYETVTNSCFRIFDETKRLSWRMDADIPEKA
RIKYKELLRVYNNNPQAVDIVPVRISRTVDDRMIGKRMSADLRPCHGDWV
EDGDLSALNAYPEKRLLLRHPKGLCPACRLFGTGSYKGRVRFGFASLEND
PEWLIPGKNPGDPFHGGPVMLSLLERPRPTWSIPGSDNKFKVPGRKFYVH
HHAWKTIKDGNHPTTGKAIEQSPNNRTVEALAGGNSFSFEIAFENLKEWE
LGLLIHSLQLEKGLAHKLGMAKSMGFGSVEIDVESVRLRKDWKQWRNGNS
EIPNWLGKGFAKLKEWFRDELDFIENLKKLLWFPEGDQAPRVCYPMLRKK
DDPNGNSGYEELKDGEFKKEDRQKKLTTPWTPWA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8eex Chain A Residue 2003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8eex RNA-activated protein cleavage with a CRISPR-associated endopeptidase.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		H703 C706 C708
Binding residue
(residue number reindexed from 1)		H666 C669 C671
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0051607 defense response to virus

View graph for
Biological Process
External links
PDB RCSB:8eex, PDBe:8eex, PDBj:8eex
PDBsum8eex
PubMed36423276
UniProtA0A401FT36

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