Structure of PDB 8ecc Chain A Binding Site BS03
Receptor Information
>8ecc Chain A (length=346) Species:
10090
(Mus musculus) [
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KLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTG
SYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKGNPLSHFLEG
EVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEI
SVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAQG
ETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKK
EFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECL
RTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
>8ecc Chain I (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8ecc
Structure of Ternary Complex of cGAS with dsDNA and Bound 5-pppI(2,5)pA
Resolution
2.44 Å
Binding residue
(original residue number in PDB)
K335 T338
Binding residue
(residue number reindexed from 1)
K181 T184
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8ecc
,
PDBe:8ecc
,
PDBj:8ecc
PDBsum
8ecc
PubMed
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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