Structure of PDB 8eaz Chain A Binding Site BS03

Receptor Information
>8eaz Chain A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QQEGNYLQHVQLDQRSLVLNTEPAECPVCYSVLAPGEAVVLRECLHTFCR
ECLQGTIRNSQEAEVSCPFIDNTYSCSGKLLEREIKALLTPEDYQRFLDL
GISIAENRSAFSYHCKTPDCKGWCFFEDDVNEFTCPVCFHVNCLLCKAIH
EQMNCKEYQEDLALRAQNDVAARQTTEMLKVMLQQGEAMRCPQCQIVVQK
KDGADWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSC
QNCH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8eaz Chain A Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8eaz The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family.
Resolution3.08 Å
Binding residue
(original residue number in PDB)		C371 C376 C391
Binding residue
(residue number reindexed from 1)		C115 C120 C135
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.31: RBR-type E3 ubiquitin transferase.
External links
PDB RCSB:8eaz, PDBe:8eaz, PDBj:8eaz
PDBsum8eaz
PubMed36631489
UniProtQ9BYM8|HOIL1_HUMAN RanBP-type and C3HC4-type zinc finger-containing protein 1 (Gene Name=RBCK1)

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