Structure of PDB 8e4m Chain A Binding Site BS03

Receptor Information
>8e4m Chain A (length=881) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLVNFIQANFDAFGDIQGKYLRLSCDTDSETLYELLTQHWHLKTPNLVIS
NFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISE
NIVAIGIAAWGMVSNRDTLSAQYIMYILDNNHTHLLLVDNGTVEAKLRNQ
LEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVE
QIADVIASLVTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESSH
LLTVIKMEIVSNAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASD
EIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLT
ELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSTRHPLQALFI
WAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEE
LANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGGSNCLELAVEATDQ
HFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKL
LWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYA
LVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKS
SLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFL
FAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTP
EWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLV
QEYCNRLNIPFPFVVFAYFYMVVNEDNETLAWEGVMKENYLVKINTKAND
NSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8e4m Chain A Residue 1203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8e4m Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Resolution3.44 Å
Binding residue
(original residue number in PDB)		Q785 N799
Binding residue
(residue number reindexed from 1)		Q612 N626
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0006874 intracellular calcium ion homeostasis
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0034220 monoatomic ion transmembrane transport
GO:0050955 thermoception
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0120162 positive regulation of cold-induced thermogenesis
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0044853 plasma membrane raft
GO:0045121 membrane raft

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8e4m, PDBe:8e4m, PDBj:8e4m
PDBsum8e4m
PubMed36227998
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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