Structure of PDB 8d2q Chain A Binding Site BS03

Receptor Information

>8d2q Chain A (length=906) Species: 351607 (Acidothermus cellulolyticus 11B)

GTVPVTWRLGVDVGERSIGLAAVSYEEDKPKEILAAVSWIHDGGVGDERS
GASRLALRGMARRARRLRRFRRARLRDLDMLLSELGWTPLPDKNVSPVDA
WLARKRLAEEYVVDETERRRLLGYAVSHMARHRGWRNPWTTIKDLKNLPQ
PSDSWERTRESLEARYSVSLEPGTVGQWAGYLLQRAPGIRLNPTQQSLSN
ATAFETRLRQEDVLWELRCIADVQGLPEDVVSNVIDAVFCQKRPSVPAER
IRPPLPALHEATGHPVVDRNLAILRKFLSSATMRWGPPQSIVVELARGAS
ESRERQAEEEAARRAHRKANDRIRAELRASGLSDPSPADLVRARLLELYD
CHCMYCGAPISWENSELDHIVPRTDGGSNRHENLAITCGACNKEKGRRPF
ASWAETSNRVQLRDVIDRVQKLKYSGNMYWTRDEFSRYKKSVVARLKRRT
SDPEVIQSIESTGYAAVALRDRLLSYGEKNGVAQVAVFRGGVTAEARRWL
DISIERLFSRVAIFAQSTSTKRLDRRHHAVDAVVLTTLTPGVAKTLADAR
SRRVSAEFWRRPSTEEPQSPAYRQWKESCSGLGDLLISTAARDSIAVAAP
LRLRPTGALHEETLRAFSEHTVGAAWKGAELRRIVEPEVYAAFLALTDPG
GRFLKVSPSEDVLPADENRHIVLSDRVLGPRDRVKLFPDDRGSIRVRGGA
AYIASFHHARVFRWGSSHSPSFALLRVSLADLAVAGLLRDGVDVFTAELP
PWTPAWRYASIALVKAVESGDAKQVGWLVPGDELDFGPEGVTTAAGDLSM
FLKYFPERHWVVTGFEDDKRINLKPAFLSAEQAEVLRTERSDRPDTLTEA
GEILAQFFPRCWRATVAKVLCHPGLTVIRRTALGQPRWRRGHLPYSWRPW
SADPWS

Ligand information

>8d2q Chain X (length=13)

agcttggtgtata

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8d2q Coupled catalytic states and the role of metal coordination in Cas9
• Resolution: 2.58 Å
• Binding residue (original residue number in PDB): R55 Q201 Q202 E839 E840 T841 D1025 R1048 R1088 R1091
• Binding residue (residue number reindexed from 1): R49 Q195 Q196 E611 E612 T613 D797 R820 R860 R863

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003677 DNA binding
• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0008270 zinc ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:8d2q, PDBe:8d2q, PDBj:8d2q
• PDBsum: 8d2q
• PubMed: 38348449
• UniProt: A0LWB3