Structure of PDB 8cxv Chain A Binding Site BS03

Receptor Information
>8cxv Chain A (length=545) Species: 272563 (Clostridioides difficile 630) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIYYTPKIIVDYIVKKTLKNHDIIKNPYPRILDISCGCGNFLLEVYDILY
DLFEENIYELKKKYDENYWTVDNIHRHILNYCIYGADIDEKAISILKDSL
TNKKDESDIKINLFCCDSLKKKWRYKFDYIVGNPPYIGHKKLEKKYKKFL
LEKYSEVYKDKADLYFCFYKKIIDILKQGGIGSVITPRYFLESLSGKDLR
EYIKSNVNVQEIVDFLGANIFKNIGVSSCILTFDKKKTKETYIDVFKIKN
EDICINKFETLEELLKSSKFEHFNINQRLLSDEWILVNKDDETFYNKIQE
KCKYSLEDIAISFQGIITGCDKAFILSKDDVKLNLVDDKFLKCWIKSKNI
NKYIVDKSEYRLIYSNDIDNENTNKRILDEIIGLYKTKLENRRECKSGIR
KWYELQWGREKLFFERKKIMYPYKSNENRFAIDYDNNFSSADVYSFFIKE
EYLDKFSYEYLVGILNSSVYDKYFKITAKKMSKNIYDYYPNKVMKIRIFR
DNNYEEIENLSKQIISILLNKSIDKGKVEKLQIKMDNLIMDSLGI
Ligand information
Ligand IDT9R
InChIInChI=1S/C17H19N5O5/c23-6-11-13(25)14(26)17(27-11)22-8-21-12-15(19-7-20-16(12)22)18-5-9-1-3-10(24)4-2-9/h1-4,7-8,11,13-14,17,23-26H,5-6H2,(H,18,19,20)/t11-,13-,14-,17-/m1/s1
InChIKeyUGVIXKXYLBAZND-LSCFUAHRSA-N
SMILES
SoftwareSMILES
CACTVS 3.385OC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(NCc4ccc(O)cc4)ncnc23
CACTVS 3.385OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccc(O)cc4)ncnc23
OpenEye OEToolkits 2.0.7c1cc(ccc1CNc2c3c(ncn2)n(cn3)C4C(C(C(O4)CO)O)O)O
OpenEye OEToolkits 2.0.7c1cc(ccc1CNc2c3c(ncn2)n(cn3)[C@H]4[C@@H]([C@@H]([C@H](O4)CO)O)O)O
ACDLabs 12.01Oc1ccc(cc1)CNc1ncnc2c1ncn2C1OC(CO)C(O)C1O
FormulaC17 H19 N5 O5
NameN-[(4-hydroxyphenyl)methyl]adenosine
ChEMBLCHEMBL224024
DrugBank
ZINCZINC000028638129
PDB chain8cxv Chain A Residue 906 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8cxv Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile- Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence.
Resolution2.26 Å
Binding residue
(original residue number in PDB)		S62 D114 I115 D149 S150 P167 Y178
Binding residue
(residue number reindexed from 1)		S35 D87 I88 D117 S118 P135 Y146
Annotation score2
Enzymatic activity
Enzyme Commision number 2.1.1.72: site-specific DNA-methyltransferase (adenine-specific).
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity
Biological Process
GO:0006304 DNA modification
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:8cxv, PDBe:8cxv, PDBj:8cxv
PDBsum8cxv
PubMed36581322
UniProtQ183J3

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