Structure of PDB 8c5s Chain A Binding Site BS03

Receptor Information
>8c5s Chain A (length=924) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
INFFEIYNSLPTLEEKKAFESALNIFNQDRQKVLENRATEAARERWKHDF
EEAKARGDISIEKNLNVKLWKWYNEMLPLVKEEINHCRSLLSEKLSDKKG
LNKVDTNRLGYGPYLTLIDPGKMCVITILELLKLNSTGGVIEGMRTARAV
ISVGKAIEMEFRSEQVLKKILWPQSIRARIGSVLISMLIQVAKVSVQGVD
PVTKAKVHGEAPAFAHGYQYHNGSKLGVLKIHKTLIRQLNGERLIASVQP
QLLPMLVEPKPWVNWRSGGYHYTQSTLLRTKDSPEQVAYLKAASDNGDID
RVYDGLNVLGRTPWTVNRKVFDVVSQVWNKGEGFLDIPGAQDEMVLPPAP
PKNSDPSILRAWKLQVKTIANKFSSDRSNRCDTNYKLEIARAFLGEKLYF
PHNLDFRGRAYPLSPHFNHLGNDMSRGLLIFWHGKKLGPSGLKWLKIHLS
NLFGFDKLPLKDRVAFTESHLQDIKDSAENPLTGDRWWTTADKPWQALAT
CFELNEVMKMDNPEEFISHQPVHQDGTCNGLQHYAALGGDVEGATQVNLV
PSDKPQDVYAHVARLVQKRLEIAAEKGDENAKILKDKITRKVVKQTVMTN
VYGVTYVGATFQIAKQLSPIFDDRKESLDFSKYLTKHVFSAIRELFHSAH
LIQDWLGESAKRISKSIRLDVDEKSFKNGNKPDFMSSVIWTTPLGLPIVQ
PYREESKKQVETNLQTVFISDPFAVNPVNARRQKAGLPPNFIHSLDASHM
LLSAAECGKQGLDFASVHDSYWTHASDIDTMNVVLREQFIKLHEVDLVLR
LKEEFDQRYKNYVKIGKLKRSTDLAQKIIRIRKDLSRKLGRSTTLADEIY
FEKKRQELLNSPLIEDRNVGEKMVTTVSLFEDITDLDALELSGMSVLLPL
RLPEIPPKGDFDVTVLRNSQYFFS
Ligand information
Receptor-Ligand Complex Structure
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PDB8c5s Structures illustrate step-by-step mitochondrial transcription initiation
Resolution3.75 Å
Binding residue
(original residue number in PDB)		R829 L840 R846 M1018 Y1022 H1163 H1188
Binding residue
(residue number reindexed from 1)		R409 L420 R426 M598 Y602 H743 H768
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0000002 mitochondrial genome maintenance
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8c5s, PDBe:8c5s, PDBj:8c5s
PDBsum8c5s
PubMed37821701
UniProtP13433|RPOM_YEAST DNA-directed RNA polymerase, mitochondrial (Gene Name=RPO41)

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