Structure of PDB 8bws Chain A Binding Site BS03

Receptor Information
>8bws Chain A (length=1424) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGEW
KEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSG
RPETYIWRYLPAPPVCIRPSVMSNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSDSVNPPIRGFCQRLKGKQGRFRGNLSGK
RVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELIV
NGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDV
VLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHV
PQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSFY
DRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNSP
VVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLGD
GKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPAD
DLKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLS
KVREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGN
RVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGREG
LVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDGL
DPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPLE
ERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALAN
LRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFL
EIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTL
GVPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDVAF
YVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQASD
VNIIGKDRIAINVFPSENDVFYRMQQLRRALPDVVVKGLPDISRAVINIR
DDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSII
REINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQL
ASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNI
SEKDLVPKRCLFESLSNEAALKAN
Ligand information
Receptor-Ligand Complex Structure
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PDB8bws Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D513 D515
Binding residue
(residue number reindexed from 1)		D492 D494
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8bws, PDBe:8bws, PDBj:8bws
PDBsum8bws
PubMed36977686
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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