Structure of PDB 8b9k Chain A Binding Site BS03

Receptor Information
>8b9k Chain A (length=951) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IHGNWTIENAKERLNIYKQTNNIRDDYKYTPVGPEHARSFLAELSIYVPA
LNRTVTARESGSNKKSASKSCALSLVRQLFHLNVIEPFSGTLKKKKDEQL
KPYPVKLSPNLINKIDEVIKGLDLPVVNPESSVIPWAPPQANWNTWHACN
IDEGELATTSIDDLSMDYERSLRDRRQNDNEYRQFLEFREKLPIAAMRSE
ILTAINDNPVVIIRGNTGCGKTTQIAQYILDDYICSGQGGYANIYVTQPR
RISAISVAERVARERCEQLGDTVGYSVRFESVFPRPYGAILFCTVGVLLR
KLEAGLRGVSHIIVDEIHERDVNSDFLLVILRDMVDTYPDLHVILMSATI
DTTKFSKYFGICPVLEVPGRAFPVQQFFLEDIIQMTDFVPSAESEDKDEA
EINYNKVCEDKYSQKTRNAMAMLSESDVSFELLEALLMHIKSKNIPGAIL
VFLPGWNLIFALMKFLQNTNIFGDTSQYQILPCHSQIPRDEQRKVFEPVP
EGVTKIILSTNIAETSITIDDIVFVIDICKARMKLFTSHNNLTSYATVWA
SKTNLEQRKGRAGRVRPGFCFTLCSRARFQALEDNLTPEMFRTPLHEMAL
TIKLLRLGSIHHFLSKALEPPPVDAVIEAEVLLREMRCLDANDELTPLGR
LLARLPIEPRLGKMMVLGAVFGCADLMAIMASYSSTFSEVFSLDIGQRRL
ANHQKALSGTKCSDHVAMIVASQMWRREKQRGEHMEARFCDWKGLQMSTM
NVIWDAKQQLLDLLQQAGFPEECMISHEVDERIDGDDPVLDVSLALLCLG
LYPNICVHKEKRKVLTTESKAALLHKTSVNCSNLAVTFPYPFFVFGEKIR
TRAVSCKQLSMVSPLQVILFGSRKIDLAANNIVRVDNWLNFDIEPELAAK
IGALKPALEDLITVACDNPSDILRLEEPYAQLVKVVKDLCVKSAGDFGLQ
R
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain8b9k Chain A Residue 1202 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8b9k Cryo-EM structure of MLE in complex with ADP:AlF4 and SL7modUUC RNA
Resolution4.04 Å
Binding residue
(original residue number in PDB)		T414 D507 E508 T722
Binding residue
(residue number reindexed from 1)		T222 D315 E316 T515
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0001069 regulatory region RNA binding
GO:0003676 nucleic acid binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
GO:0033679 3'-5' DNA/RNA helicase activity
GO:0034458 3'-5' RNA helicase activity
GO:0043138 3'-5' DNA helicase activity
GO:0106222 lncRNA binding
Biological Process
GO:0007549 sex-chromosome dosage compensation
GO:0008340 determination of adult lifespan
GO:0009047 dosage compensation by hyperactivation of X chromosome
GO:0010468 regulation of gene expression
GO:0031453 positive regulation of heterochromatin formation
GO:0032508 DNA duplex unwinding
GO:0042714 dosage compensation complex assembly
GO:0045433 male courtship behavior, veined wing generated song production
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048675 axon extension
GO:0050684 regulation of mRNA processing
GO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
GO:2000765 regulation of cytoplasmic translation
Cellular Component
GO:0000228 nuclear chromosome
GO:0000785 chromatin
GO:0000805 X chromosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016456 X chromosome located dosage compensation complex, transcription activating
GO:0072487 MSL complex
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8b9k, PDBe:8b9k, PDBj:8b9k
PDBsum8b9k
PubMed37989319
UniProtP24785|MLE_DROME Dosage compensation regulator mle (Gene Name=mle)

[Back to BioLiP]