Structure of PDB 8asg Chain A Binding Site BS03

Receptor Information

>8asg Chain A (length=1544) Species: 992210 (SFTS virus AH12)

MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLRRLSEVFPITHDG
SDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYRDPISR
RVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANEIYTKA
RSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEIKMLEQ
FLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEINRCEAI
DKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESIDIKTDSGFGSL
MDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISDDPEKDTPKEAK
ITYRRFKPALSSSARQEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLD
VEDIGDFLTFNNLLTDSRYGDESIQRAVSILLEKASAMQDTELTHALNDS
FKRNLSSNVVQWSLWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVII
KPTKSSSHIFYSLGIRKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCK
LTNLVNLPCTMLNSIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLED
KSKTEEIITLTRYTQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRK
HLDCMVRIASQPFSLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYY
KNKEESTELNALGEMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSF
LRAACSSLEREIAQRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFS
KDWELYSEVQTKEYHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGC
MRICLFKKNQHREIYVMDANARLVQFGVETMARCVCELSPHETVANPRLK
NSIIENHGLKSARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPA
KFHRFIWAAISMFRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHG
NRDVSWMDKGRTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKE
GYMGESISGVVDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKF
LNPLFGIYSSEKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISET
EALASRQEDYSNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLF
GTFMGMLISDPDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAY
YFNEIQGHSVMVYWGDRKKYQALLNRMGLPEDWVEQIDENPGVLYRRAAN
KKELLLKLAEKVHSPGVTSSLSKGHVVPRVVAAGVYLLSRHCFRFSGSTQ
KASLIKLLMMSSISAMKHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHL
TGKFVVRERNIVRSRIDLFAEDLVSEVWFGEWDKLRASFAWLSTDPSETL
RDGPFLSHVQFRNFIAHRSVRLLGAPVTISQVVRMNFFPGFSLE

Ligand information

>8asg Chain T (length=5)

ugugu

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8asg Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): K386 E387 K405 Y408 S530 K533 Q534 K544 L1254 V1340 R1345 V1413 Y1414 R1418 C1420
• Binding residue (residue number reindexed from 1): K381 E382 K400 Y403 S525 K528 Q529 K539 L1246 V1312 R1317 V1385 Y1386 R1390 C1392

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

Cellular Component

• GO:0044165 host cell endoplasmic reticulum
• GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
• GO:0044177 host cell Golgi apparatus
• GO:0044423 virion component

External links

• PDB: RCSB:8asg, PDBe:8asg, PDBj:8asg
• PDBsum: 8asg
• PubMed: 36651274
• UniProt: U3GU88