Structure of PDB 8asb Chain A Binding Site BS03

Receptor Information
>8asb Chain A (length=1715) Species: 992210 (SFTS virus AH12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEVLCGRINVENGLSLGEPGLYDQIYDRPGLPDLDVTVDATGVTVDIG
AVPDSASQLGSSINAGLITIQLSEAYKINHDFTFSGLSKTTDRRLSEVFP
ITHDGSDGMTPAVIHTRLDGTIVVVEFSTTRSHNIGGLEAAYRTKIEKYR
DPISRRVDIMENPRVFFGVIVVSSGGVLSNMPLTQDEAEELMYRFCIANE
IYTKARSMDADIELQKSEEELEAISRALSFFSLFEPNIERVEGTFPNSEI
KMLEQFLSTPADVDFITKTLKAKEVEAYADLCDSHYLKPEKTIQERLEIN
RCEAIDKTQDLLAGLHARSNKQTSLNRGTVKLPPWLPKPSSESISGFGSL
MDHGAYGELWAKCLLDVSLGNVEGVVSDPAKELDIAISDYRRFKPALSSS
ARQEFSLQGVEGKKWKRMAANQKKEKESHETLSPFLDVEDIGDFLTFNNL
LTDSRYGDESIQRAVSILLEKASAMQDTELTHALNDSFKRNLSSNVVQWS
LWVSCLAQELASALKQHCRAGEFIIKKLKFWPIYVIIKPTKSSSHIFYSL
GIRKADVTRRLTGRVFSDTIDAGEWELTEFKSLKTCKLTNLVNLPCTMLN
SIAFWREKLGVAPWLVRKPCSELREQVGLTFLISLEDKSKTEEIITLTRY
TQMEGFVSPPMLPKPQKMLGKLDGPLRTKLQVYLLRKHLDCMVRIASQPF
SLIPREGRVEWGGTFHAISGRSTNLENMVNSWYIGYYKNKEESTELNALG
EMYKKIVEMEEDKPSSPEFLGWGDTDSPKKHEFSRSFLRAACSSLEREIA
QRHGRQWKQNLEERVLREIGTKNILDLASMKATSNFSKDWELYSEVQTKE
YHRSKLLEKMATLIEKGVMWYIDAVGQAWKAVLDDGCMRICLFKKNQHGG
LREIYVMDANARLVQFGVETMARCVCELSPHETVANPRLKNSIIENHGLK
SARSLGPGSININSSNDAKKWNQGHYTTKLALVLCWFMPAKFHRFIWAAI
SMFRRKKMMVDLRFLAHLSSKSESRSSDPFREAMTDAFHGNRDVSWMDKG
RTYIKTETGMMQGILHFTSSLLHSCVQSFYKSYFVSKLKEGYMGESISGV
VDVIEGSDDSAIMISIRPKSDMDEVRSRFFVANLLHSVKFLNPLFGIYSS
EKSTVNTVYCVEYNSEFHFHRHLVRPTLRWIAASHQISETEALASRQEDY
SNLLTQCLEGGASFSLTYLIQCAQLLHHYMLLGLCLHPLFGTFMGMLISD
PDPALGFFLMDNPAFAGGAGFRFNLWRACKTTDLGRKYAYYFNEISVMVY
WGDRKKYQALLNRMGLPEDWVEQIDENPGVLYRRAANKKELLLKLAEKVH
SPGVTSSLSKGHVVPRVVAAGVYLLSRHCFRFSQKASLIKLLMMSSISAM
KHGGSLNPNQERMLFPQAQEYDRVCTLLEEVEHLTGKFVERNIVRSRIDC
KAEDLVSEVWFGLKRTKLGPRLLKEEWDKLRASFAWLSTDPSETLRDGPF
LSHVQFRNFIAHVDSRSVRLLGAPTTISQVVRMNFFPGFSLEKSRTMTLC
LLSNYLSSRGGSILDQIERAQSGTLGGFSKPQKTFVRPGGGVGYKGKGVW
TGVMEDTHVQILIDGDGTSNWLEEIRLSSDARLYDVIESIRRLCDDLGIN
NRVASAYRGHCMVRLSGFKIKPASRTDGCPVRIMPDEVKMRVRGDILNLS
VTIQEGRVMNILSYR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8asb Structural insights into viral genome replication by the severe fever with thrombocytopenia syndrome virus L protein.
Resolution3.6 Å
Binding residue
(original residue number in PDB)		D1126 N1182 S1183 R1197 W1198
Binding residue
(residue number reindexed from 1)		D1108 N1164 S1165 R1179 W1180
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
Cellular Component
GO:0044165 host cell endoplasmic reticulum
GO:0044172 host cell endoplasmic reticulum-Golgi intermediate compartment
GO:0044177 host cell Golgi apparatus
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8asb, PDBe:8asb, PDBj:8asb
PDBsum8asb
PubMed36651274
UniProtU3GU88

[Back to BioLiP]