Structure of PDB 8aj3 Chain A Binding Site BS03

Receptor Information

>8aj3 Chain A (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

Ligand information

• Ligand ID: MNW
• InChI: InChI=1S/C6H6O3.4H2O.V/c1-4-6(8)5(7)2-3-9-4;;;;;/h2-3H,1H3,(H-,7,8);4*1H2;/q;;;;;+6/p-5
• InChIKey: YLEPPWNUQSQYPV-UHFFFAOYSA-I
• SMILES:
  CACTVS 3.385: Cc1[o+]ccc2O[V](O)(O)(O)(O)Oc12
  OpenEye OEToolkits 2.0.7: Cc1c2c(cc[o+]1)O[V](O2)(O)(O)(O)O
• Formula: C6 H9 O7 V
• Name: 8,8,8,8-tetrakis($l^{1}-oxidanyl)-2-methyl-3,7,9-trioxa-8$l^{6}-vanadabicyclo[4.3.0]nona-1,5-diene
• PDB chain: 8aj3 Chain A Residue 205

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8aj3 Multiple and Variable Binding of Pharmacologically Active Bis(maltolato)oxidovanadium(IV) to Lysozyme.
• Resolution: 1.13 Å
• Binding residue (original residue number in PDB): R73 N74
• Binding residue (residue number reindexed from 1): R73 N74
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:8aj3, PDBe:8aj3, PDBj:8aj3
• PDBsum: 8aj3
• PubMed: 36205235
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)