Structure of PDB 7zxw Chain A Binding Site BS03

Receptor Information

>7zxw Chain A (length=283) Species: 759272 (Thermochaetoides thermophila DSM 1495) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SVSKTEHAEINIFSVASGHLYERMLNIMMASVMHHTNHTVKFWFIEQFLS
PSFKDFIPHMAAEYGFKYEMVTYKWPHWLRQQKEKQREIWGYKILFLDVL
FPLSLDKVIFVDADQIVRTDMYDLVEHPLDGAPYGFAPMCDSRVEMEGYR
FWKTGYWANYLKGKPYHISALYVVDLQRFRELAAGDRLRQQYHALSADPN
SLANLDQDLPNHMQFTIPIATLPQEWLWCETWCSDETLKDARTIDLCNNP
MTKEPKLDRARRQVPEWTKYDEEIAELARRVRE

Ligand information

Ligand ID

JM3

InChI

InChI=1S/C14H16N2O2/c17-13-4-3-11(10-16-6-8-18-9-7-16)12-2-1-5-15-14(12)13/h1-5,17H,6-10H2

InChIKey

AKUILKRKGZEPQD-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.385	Oc1ccc(CN2CCOCC2)c3cccnc13
OpenEye OEToolkits 2.0.7	c1cc2c(ccc(c2nc1)O)CN3CCOCC3

Formula

C14 H16 N2 O2

Name

5-(morpholin-4-ylmethyl)quinolin-8-ol

PDB chain

7zxw Chain A Residue 1504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7zxw Crystal polymorphism in fragment-based lead discovery of ligands of the catalytic domain of UGGT, the glycoprotein folding quality control checkpoint.
Resolution	2.246 Å
Binding residue (original residue number in PDB)	F1341 Y1346 W1347 Y1350 L1392 D1398 H1402
Binding residue (residue number reindexed from 1)	F151 Y156 W157 Y160 L202 D208 H212
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003980	UDP-glucose:glycoprotein glucosyltransferase activity

	Biological Process
GO:0006486	protein glycosylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:7zxw, PDBe:7zxw, PDBj:7zxw
PDBsum	7zxw
PubMed	36589243
UniProt	G0SB58

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