Structure of PDB 7z1l Chain A Binding Site BS03

Receptor Information
>7z1l Chain A (length=1436) Species: 580240 (Saccharomyces cerevisiae W303) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKA
NGALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATI
QILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKK
QRRCLHCGALNGVVKKAAAGAGSAALKIIHDTFRWVGKKSAPEKDIWVGE
WKEVLAHNPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPS
GRPETYIWRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIK
AGLDKGISINNMMEHWDYLQLTVAMYINSDSVNPAMLPGSVKPIRGFCQR
LKGKQGRFRGNLSGKRVDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPE
KVTRYNRHKLQELIVNGPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNL
QIGDVVERHLEDGDVVLFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCT
PYNADFDGDEMNLHVPQTEEARAEAINLMGVKNNLLTPKSGEPIIAATQD
FITGSYLISHKDSFYDRATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTG
KQVFSLLIKPNHNSPVVINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRG
SQILSGVMDKSVLGDGKKHSVFYTILRDYGPQEAANAMNRMAKLCARFLG
NRGFSIGINDVTPADDLKQKKEELVEIAYHKCDELITLFNKGELETQPGC
NEEQTLEAKIGGLLSKVREEVGDVCINELDNWNAPLIMATCGSKGSTLNV
SQMVAVVGQQIISGNRVPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGL
SPPEFLFHAISGREGLVDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRT
SANGIVQFTYGGDGLDPLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLP
YAIMETANEILGPLEERLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYH
SLREYINGKATALANLRKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSV
SQLYRISEKSVRKFLEIALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTL
KTFHFAGVASMNVTLGVPRIKEIINASKVISTPIINAVLVNDNDERAARV
VKGRVEKTLLSDVAFYVQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIA
VAITRASKLKIQASDVNIIGKDRIAINVFPENDVFYRMQQLRRALPDVVV
KGLPDISRAVINIRDDGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEV
FSVLGIEAARYSIIREINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGIT
RFGLSKMRDSVLQLASFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMS
IGTGSFKVVKGTNISEKDLVPKRCLFESLSNEAALK
Ligand information
Receptor-Ligand Complex Structure
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PDB7z1l Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		A169 G170 G187 K188 K358 K360 R372 R378 Q477 T879 A880 Y884 R1373 E1390
Binding residue
(residue number reindexed from 1)		A169 G170 G187 K188 K352 K354 R366 R372 Q471 T873 A874 Y878 R1351 E1368
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z1l, PDBe:7z1l, PDBj:7z1l
PDBsum7z1l
PubMed36070694
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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