Structure of PDB 7yho Chain A Binding Site BS03

Receptor Information
>7yho Chain A (length=361) Species: 3702,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KWWEEERNVFRGRADSFIARMHLVQGDRRFTPWKGSVVDSVVGVFLTQNV
SDHLSSSAFMSLASQFPVPFVSTMDTVDWKAIRAADVKEVAETIKSRGMN
HKLAERIQGFLDRLVNDHGSIDLEWLRDVPPDKAKEYLLSFNGLGLKSVE
CVRLLTLHHLAFPVNTNVGRIAVRLGWVEMYPMLESIQKYLWPRLCKLDQ
KTLYELHYQMITFGKVFCTKSKPNCNACPMKGECRHFASAFHRVYELPDE
HPLLAQLEKREPDDPCSYLLAIWGTILIPCRTAMRGSFPLNGTYFQVNEV
FADHASSLNPINVPPRRTVYFGTSVPTIFKGLSTEKIQACFWKGYVCVRG
FDRKTRGPKPL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain7yho Chain A Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7yho Molecular basis of the plant ROS1-mediated active DNA demethylation.
Resolution3.3 Å
Binding residue
(original residue number in PDB)		F1033 F1037 C1038 P1043 C1045 C1048 K1051 C1054
Binding residue
(residue number reindexed from 1)		F213 F217 C218 P223 C225 C228 K231 C234
Annotation score1
Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0019104 DNA N-glycosylase activity
GO:0035514 DNA demethylase activity
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7yho, PDBe:7yho, PDBj:7yho
PDBsum7yho
PubMed36624257
UniProtQ05066|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY);
Q9SJQ6

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